Bright Bek (watchdrop48)
Univariate analysis revealed that longer procedure time was associated with infection (p=0.0008), seroma (p=0.002), necrosis/dehiscence (p=0.01), and reoperation (p=0.002). These associations persisted following multivariate analyses. There was a trend toward history of bariatric surgery being associated with minor reoperation (p=0.054). No significant increase in the incidence of major reoperation was found in association with overweight or obese patient habitus, history of bariatric surgery, or prolonged procedure time. BMI was not found to be an individual risk factor for morbidity in this patient population. In abdominal body contouring surgery, length of surgery longer six hours is associated with higher incidence of seroma and infectious complications, as well as higher rates of minor reoperation. In abdominal body contouring surgery, length of surgery longer six hours is associated with higher incidence of seroma and infectious complications, as well as higher rates of minor reoperation. Identification of system-wide causal relationships can contribute to our understanding of long-distance, intercellular signaling in biological organisms. Dynamic transcriptome analysis holds great potential to uncover coordinated biological processes between organs. However, many existing dynamic transcriptome studies are characterized by sparse and often unevenly spaced time points that make the identification of causal relationships across organs analytically challenging. Application of existing statistical models, designed for regular time series with abundant time points, to sparse data may fail to reveal biologically significant, causal relationships. With increasing research interest in biological time series data, there is a need for new statistical methods that are able to determine causality within and between time series data sets. Here, a statistical framework was developed to identify (Granger) causal gene-gene relationships of unevenly spaced, multivariate time series data from two different tiile transcripts, suggesting that the identified causal genes may be directly involved in long-distance nitrogen signaling through intercellular interactions. The model predictions and subsequent network analysis identified nitrogen-responsive genes that can be further tested for their specific roles in long-distance nitrogen signaling. The method was developed with the R statistical software and is made available through the R package "irg" hosted on the GitHub repository https//github.com/SMAC-Group/irg where also a running example vignette can be found (https//smac-group.github.io/irg/articles/vignette.html). A few signals from the original data set are made available in the package as an example to apply the method and the complete Arabidopsis thaliana data can be found at https//. Supplementary data are available at Bioinformatics online. Supplementary data are available at Bioinformatics online. Investigating the relationships between two sets of variables helps to understand their interactions and can be done with canonical correlation analysis (CCA). However, the correlation between the two sets can sometimes depend on a third set of covariates, often subject-related ones such as age, gender, or other clinical measures. In this case, applying CCA to the whole population is not optimal and methods to estimate conditional CCA, given the covariates, can be useful. We propose a new method called Random Forest with Canonical Correlation Analysis (RFCCA) to estimate the conditional canonical correlations between two sets of variables given subject-related covariates. The individual trees in the forest are built with a splitting rule specifically designed to partition the data to maximize the canonical correlation heterogeneity between child nodes. We also propose a significance test to detect the global effect of