Moore Lindhardt (turretwaiter70)

24 ± 0.15% vs. -0.35 ± 0.11%, p less then 0.0001; glycated albumin, -4.4 ± 0.6% vs. -2.4 ± 0.5%, p less then 0.01). Body weight (-1.3 ± 0.4 kg vs. -1.5 ± 0.3 kg, p=0.69) or body fat mass/lean tissue mass; urinary albumin excretion [(median, IQR) -5.3 [-60.6, 9.9] mg/g-creatinine vs. -12.9 [-70.8, -2.0] mg/g-creatinine, p=0.23]; and frequency of hypoglycemia did not differ significantly between the groups over 24 weeks. There were no cases of study discontinuation owing to adverse effects. CONCLUSIONS Liraglutide addition to ongoing insulin therapy effectively reduced glycated hemoglobin and glycated albumin levels than empagliflozin in patients with inadequately controlled type 2 diabetes. This article is protected by copyright. All rights reserved.Prostate cancer is a serious threat to men's health, so it is necessary to develop the techniques for early detection of this malignancy. Radiolabeled peptides are the useful tools for diagnosis of prostate cancer. In this research we designed a new HYNIC-conjugated GnRH analogue and labeled it by 99m Tc with tricine/EDDA as coligands. We used Aminohexanoic acid (Ahx) as a hydrocarbon linker to generate 99m Tc-(tricine/EDDA)-HYNIC-Ahx-[D-Lys6 ]GnRH. The radiopeptide exhibited high radiochemical purity and stability in solution and serum. Two human prostate cancer cell lines LN-CaP and DU-145 were used for cellular experiments. The binding specificity and affinity of radiopeptide for LN-CaP were superior to DU-145 cells. The Kd values for LN-CaP and DU-145 cells were 41.91±7.03 nM and 55.96±10.56 nM respectively. High kidney uptake proved that the main excretion route of radiopeptide was through the urinary system. The tumor/muscle ratio of 99m Tc-HYNIC-Ahx- [DLys6 ]GnRH was 4.14 at 1 h p.i. that decreased to 2.41 at 4 h p.i. in LN-CaP tumor xenografted nude mice. The blocking experiment revealed that the tumor uptake was receptor mediated. The lesion was visualized clearly using 99m Tc-[D-Lys6 ]GnRH at 1 h p.i. Accordingly, this research highlights the capability of 99m Tc-(tricine/EDDA)-HYNIC-Ahx-[D-Lys6 ]GnRH peptide as a promising agent for GnRHR-expressing tumor imaging. This article is protected by copyright. All rights reserved.AIM The lack of risk profile data regarding changes in multiple polyps identified by colonoscopy constrains the creation of evidence-based guidelines. This retrospective case-control study addresses this issue by characterizing the relationship between size, location and histology of multiple polyps, in addition to population-associated features in a large teaching hospital-based Chinese population. METHODS A large, case-control retrospective analysis was conducted on polyps obtained from 8308 patients who presented at the Digestive Endoscopy Center, Changhai Hospital, Shanghai, China from January 2013 to August 2015. A total of 10 572 polyps were analyzed, with risk factors extrapolated through chart review of patient electronic medical records. RESULTS Single polyps were identified in 6843 patients (82.4%) while multiple polyps were found in 1465 (17.6%). Multivariate analysis indicated that males were more likely to have multiple polyps (p less then 0.001). Compared with patients with single polyps, the numbers of those with multiple polyps increased significantly as age increased (p less then 0.001). Small (6-9 mm) non-advanced adenomas were more likely to be found as multiple adenomas than were diminutive ( less then 5 mm) non-advanced adenomas (p less then 0.000). While the majority of the advanced and non-advanced adenomas were diagnosed in patients with single adenomas (56.0% and 65.4%, respectively), the advanced adenomas were more likely to be in multiples compared with non-advanced adenomas (p less then 0.001). CONCLUSIONS Our data indicate that particular features of colorectal polyps such as their large size, advanced histology and patient demographics including gender and age are risk factors associated with multiple polyp