Sargent Fuglsang (turnipjudo14)

PURPOSE There is an increase interest on the potential chemoprotective effect of selective phosphodiesterase 5 (PDE5) inhibitors. Several authors have shown in vivo the immune-mediated anti-tumor effect of these inhibitors on tumors arising from the digestive tract. OBJECTIVES To test the potential effect of selective PDE5 inhibitors against colorectal cancer (CRC) onset previously observed. METHODS We used data from The Health Improvement Network database and identified an established cohort of 200 000 new users of low-dose aspirin and a matched comparison cohort aged 40-84 years between 1 January 2000 and 31 December 2011. A follow-up to identify CRC cases was performed within an extensive validation exercise. Nested case-control analyses compared PDE5 inhibitors vs non-use on CRC risk were performed. RESULTS Restricting to males (59.3% controls and 59.5% cases), no association was observed among current users of PDE5 inhibitors (1.05 [95% CI 0.69-1.60]) and neither among recent (1.36 [95% CI 0.81-2.28]) or past users (1.06 [95% CI 0.72-1.58]). No duration response effect was found. CONCLUSIONS Our results do not support an increased risk of CRC associated with the use of PDE5 inhibitors among men with erectile dysfunction. © 2020 John Wiley & Sons Ltd.Vitiligo is a common chronic depigmenting skin disease. We explored the utility of near-infrared (NIR) spectroscopy in the identification of spectral changes associated with disease activity in vitiligo patients. In vivo spectral measurements were performed directly on the perilesional skin of 70 vitiligo patients. Relative intensities (second derivative) at 1139, 1344, 1646 and 1839 nm appeared to be significantly lower in the perilesional region of patients with active vitiligo compared with stable disease, while the intensity at 1884 nm seemed to be significantly higher. A classification model based on the spectral ranges around those peaks generated a correct prediction in 82.9% of the cases. In conclusion, we can state that NIR spectroscopy could have potential in the assessment of disease activity. However, large-scale prospective studies are necessary to confirm our preliminary results. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.AIM & OBJECTIVE To evaluate the impact a nurse prescriber led protocol compared to a traditional physician led non-protocol based approach had in maintaining targeted haemoglobin levels in patients on maintenance haemodialysis. BACKGROUND Anaemia is a common complication of chronic kidney disease and has a profound impact on the patients' wellbeing. CID44216842 Current practices place a greater emphasis on the decision-making role of nurses in renal anaemia management. The introduction of nurse prescribing in this area is a relatively new concept. DESIGN A retrospective cohort design, covering an eight-month period pre and post the introduction of a nurse prescriber led anaemia protocol; study adheres to the STROBE Statement. METHODS Using a non-probability convenience sample, data extracted from the medical records and electronic patient records system (eMed) related to 74 patients at a single outpatient haemodialysis centre located within an acute general teaching hospital. The primary outcome was patients' haemoglobin, standardised and sustained approach to anaemia management in outpatient haemodialysis settings without compromising patient care. This article is protected by copyright. All rights reserved.TREM2 was identified as a risk factor for late onset Alzheimer's disease (AD). Here we compared TREM2 cases with a variant (TREM2+ ) and cases without a TREM2 variant (TREM2- ), considering pathological burden, inflammatory response and altered canonical pathways and biochemical functions between the cohorts. We hypothesised that TREM2+ cases would have a loss of function, indicating an altered inflammatory profile compared to TREM2- cases. Immunohistochemistry was performed using antibodie