Churchill Bengtsson (tipapple0)

This approach demonstrates that in principle an easy colorimetric detection of bacterial contaminants can be achieved through the use of bio-responsive plasmonic materials, such as silver, whose selective electrostatic interaction with bacterial cell wall is well-known and occurs without the need of chemical functionalisation.Colloids formed of solid/fluid particle dispersions in oriented nematic liquid crystals are known to be an ideal means of realizing fundamentally significant topological defect geometries. We find, experimentally, that twist-bend nematic (NTB) droplets formed in the N-NTB biphasic regime, either of pure compounds or mesogenic mixtures, completely mimic colloidal particles in their ability to generate a rich variety of defects. In the biphasic regime, the topological features of both liquid crystal colloids and chiral nematic droplets are revealed by (i) topological dipoles, quadrupoles and their patterned clusters formed in planar nematic liquid crystals orientationally perturbed by coexisting NTB drops, (ii) the transformation of hyperbolic hedgehogs into knotted Saturn rings encircling the NTB drops dispersed in a 90°-twisted nematic matrix and (iii) the Frank-Pryce defect texture evident in smaller (relative to sample thickness) NTB drops. In larger drops with fingerlike outgrowths, additional line defects appear; most of these are deemed to be pairs of disclinations to which are attached pairs of screw dislocations intervening in the growth process of the NTB droplets.Understanding the interactions of eukaryotic cellular membranes with nanomaterials is required to construct efficient and safe nanomedicines and molecular bioengineering. Intracellular uptake of nanocarriers by active endocytosis limits the intracellular distribution to the endosomal compartment, impairing the intended biological actions of the cargo molecules. Nonendocytic intracellular migration is another route for nanomaterials with cationic or amphiphilic properties to evade the barrier function of the lipid bilayer plasma membranes. Direct transport of nanomaterials into cells is efficient, but this may cause cytotoxic or biocidal effects by temporarily disrupting the biological membrane barrier. We have recently discovered that nonendocytic internalization of synthetic amphipathic polymer-based nanoaggregates that mimic the structure of natural phospholipids can occur without inducing cytotoxicity. Analysis using a proton leakage assay indicated that the polymer enters cells by amphiphilicity-induced membrane fusion rather than by transmembrane pore formation. These noncytotoxic cell-penetrating polymers may find applications in drug delivery systems, gene transfection, cell therapies, and biomolecular engineering.The bidirectional intelligent regulation of hydrogels is a critical challenge in on-demand functional hydrogels. In this paper, a photo-triggered hydrogel for bidirectional regulation based on IR820-α-cyclodextrin/polyethylene glycol methyl acrylate was developed. This thermosensitive hydrogel can soften from gel to sol under near-infrared irradiation based on the photothermal effect of IR820, while the hydrogel can stiffen based on the photo-crosslinking of polyethylene glycol methyl acrylate under UV laser irradiation. After implanting in vivo, the softness and stiffness of the hydrogel can be regulated in a bidirectional manner by the switching of the irradiation wavelength. check details Moreover, the location and status of the hydrogel was tracked in vivo by fluorescence imaging due to the fluorescence labeling of IR820. The controlled and visible hydrogel could be potentially applied to different biomedical fields for precise treatment.Mass spectrometry (MS) techniques are highly prevalent in crime laboratories, particularly those coupled to chromatographic separations like gas chromatography (GC) and liquid chromatography (LC). These methods are considered "gold standard" analytical techniques for forensic ana