Acosta Braun (throneline89)

Nucleotide diversity analysis of BmAbl1 and its 50 kb flanking regions indicated that BmAbl1 has experienced strong artificial selection during silkworm domestication. This study is the first to identify the genes controlling silk yield in the major QTL of the Z chromosome using forward genetics.As pump thrombosis is reduced in current-generation ventricular assist devices (VAD), adverse events such as bleeding or stroke remain at unacceptable rates. Thrombosis around the VAD inlet cannula (IC) has been highlighted as a possible source of stroke events. Recent computational fluid dynamics (CFD) studies have attempted to characterize the thrombosis risk of different IC-ventricle configurations. However, purely CFD simulations relate thrombosis risk to ad hoc criteria based on flow characteristics, with little consideration of biochemical factors. This study investigates the genesis of IC thrombosis including two elements of the Virchow's triad endothelial injury and hypercoagulability. To this end a multi-scale thrombosis simulation that includes platelet activity and coagulation reactions was performed. Our results show significant thrombin formation in stagnation regions (|u| less then 0.005 m/s) close to the IC wall. In addition, high shear-mediated platelet activation was observed over the leading-edge tip of the cannula. The current study reveals the importance of biochemical factors to the genesis of thrombosis at the ventricular-cannula junction in a perioperative state. This study is a first step toward the long-term objective of including clinically relevant pharmacological kinetics such as heparin or aspirin in simulations of inflow cannula thrombosis.The economic and social well-being of rural, "resource-cursed" communities can depend on the boom-bust cycles of a single industry like oil and gas. This study used a constructivist, inductive approach to identify the challenges placed on families in one such community and the processes that strengthen family resilience. Semi-structured interviews were conducted with 35 adult residents (30-76 years old, 19 women) from a community in Alberta, Canada, that has specialized in oil and gas extraction for 70 years and experienced its worst economic downturn while the study was underway. Results showed that many families have experienced an endless cycle of poor work-life balance and income instability throughout the economic cycle. Family life often lacked social cohesion as a consequence of demanding work schedules and economic pressures. TBK1/IKKε-IN-5 Additional challenges were the perceived negative effects of rigid gender roles, substance abuse, family conflicts, and domestic violence. Crucial strengthening processes for family resilience were fundamental financial and living standard adaptations (e.g., living within or below one's economic means; having both spouses become earners), maintaining regular contact by having a flexible home routine, and mutually agreeing to change roles during busts (former earners take responsibility for caregiving and running of the household and vice versa). Alternatively, accepting economic volatility and its impact on normal family life processes were essential for family resilience. Findings suggest the need for clinicians to help families foster resilience in communities that depend on resource extraction industries with concurrent adaptations required by individuals, families, and socio-political and economic systems.Cooley's argument that persons with pre-dementia have a Kantian duty to die has led to much debate. Cooley gives two reasons for his claim, the first being that a person with pre-dementia should end his/her life when he/she will inevitably and irreversibly lose rationality and be unable to live morally as a result. This paper argues that this reason derives from an unsubstantiated premise and general confusion regarding the condition for a Kantian duty to die. Rather, a close reading of Kant reveals that such a condit