Henningsen Axelsen (threadwallet76)

The anatomy of the hair follicle and the dynamics of its barrier provide a special space for interactions between macromolecules and the underlying tissue. Translocation across the hair follicle epithelium and immune recognition have been confirmed for proteins, nucleic acids, engineered particles, virus particles and others. Tissue responses can be modulated by pro-inflammatory stimuli as demonstrated in penetration and transcutaneous immunization studies. Even under physiological conditions, hair follicle openings are filled with exogenous material ranging from macromolecules, engineered particles to natural particles including diverse communities of microbes. The exposed position of the infundibulum suggests that local inflammatory insults could disturb the finely tuned balance and may trigger downstream responses that initiate or facilitate local outbreaks of inflammatory hair diseases typically occurring in close spatial association with the infundibulum as observed in cicatricial alopecia. The question as to how microbial colonization or deposition of contaminants on the surface of the hair follicle epithelium interact with the barrier status under the influence of individual predisposition, may help us understand local flare-ups of inflammatory hair diseases. Specifically, learning more about skin barrier alterations in the different types of inflammatory hair diseases and cross-talk with exogenous compounds could give new insights in this less explored aspect of hair follicle homeostasis. Such knowledge may not only be used to develop supportive measures to maintain a healthy scalp. It may have wider implications for our understanding on how external factors influence inflammation and immunological responses in the skin.Supravalvular pulmonary stenosis acquired as a postoperative cardiac procedure complication is relatively common. However, that occurring after a surgically created pleuro-pericardial window has not been described until now, to the best of our knowledge. We present a case of acquired supravalvular pulmonary stenosis that developed 9 years after the pleuro-pericardial window creation for pyopericardium due to a constricting pericardial band. The child underwent successful surgical relief of the stenosis along with repair of the atrial and ventricular septal defects.Equilibrium sampling based on silicone polydimethylsiloxane (PDMS) has been used to determine the concentrations of freely dissolved hydrophobic organic compounds (HOCs) and assess the thermodynamic potentials for bioaccumulation of these compounds in the aquatic environment. This allows the use of PDMS-based sampling techniques in assisting conventional sampling and extraction methods for the determination of the concentrations of HOCs in aquaculture products. The present study is an ex situ demonstration of how well PDMS can inform the tissue residues and dietary risks of legacy or current-use organic chemicals in aquaculture species from farm ponds in eastern China. For legacy contaminants such as polybrominated diphenyl ethers (PBDEs, n = 10), good agreement between the predicted concentrations based on PDMS and the measured lipid-normalized concentrations was observed for 60% of the studied biota, including both pelagic and benthic species. For pesticides currently used, such as pyrethroid (PE) (n = 4) and organophosphate pesticides (OPPs, n = 7), the measured tissue residues were consistently higher than those predicted by PDMS, possibly caused by the continuous input from the surroundings. For the organochlorine pesticides (OCPs, n = 5), the only detected chemical was also underestimated. Adjusted by ingestion rates of aquaculture products and toxicology data, the target hazard quotients of these chemicals predicted from PDMS were generally comparable to those derived from measured concentrations in tissue because of the predominance of PBDEs. Overall, PDMS-based equilibrium sampling offered an alternative approach for the prediction