Hutchison Gade (testbox87)
Sorghum is an important food crop in many parts of Africa and Asia. Landraces of sorghum are known to exhibit variation in food quality traits including starch and protein content and composition. In this study, a panel of diverse sorghum breeding lines and 788 sorghum conversion (SC) lines representing the global germplasm diversity of the crop were evaluated for variation in starch quality based on alkali spreading value (ASV). A small number of genotypes with stable expression of the ASV+ phenotype across seasons were identified; mostly representing Nandyal types from India. Genetic studies showed the ASV+ phenotype was inherited as a recessive trait. Whole genome resequencing of ASV+ donor lines revealed SNPs in genes involved in starch biosynthesis. A genome wide association study (GWAS) identified a significant SNP associated with ASV near Sobic.010G273800, a starch branching enzyme I precursor, and Sobic.010G274800 and Sobic.010G275001, both annotated as glucosyltransferases. Physiochemical analyses of accessions with contrasting ASV phenotypes demonstrated an environment dependent lower starch gelatinization temperature (GT), amylose content of approximately 22%, and good gel consistency. The starch quality attributes of these lines could be valuable in food products that require good gel consistency and viscosity. The aim of this study is to investigate factors that are associated with having a non-localising Tc-sestamibi scan. A retrospective study was performed on patients that underwent parathyroid surgery performed within a single institution between 2001 and 2018. Single tertiary centre for parathyroid surgery. 230 patients underwent surgery for primary hyperparathyroidism due to a solitary parathyroid adenoma and had preoperative Tc-sestamibi imaging. Variables including age, gender, intra-operative location of parathyroid adenoma, adenoma weight and pre- and postoperative calcium and parathyroid hormone levels were investigated through univariate and multivariate analysis to identify any association with having a non-localising (negative) Tc-sestamibi scan result. Multivariate analysis identified that right-sided adenomas (P=.038), superior adenomas (P=.042) and a lower preoperative PTH level (P=.034) were all individual factors associated with having a negative Tc-sestamibi scan result. Although the weight of the adenoma was significant on univariate analysis (P=.029), this was not demonstrated on multivariate analysis (P=.422). Factors that were associated with having non-localising Tc-sestamibi scan were right-sided adenomas, superior adenomas and lower preoperative PTH level. Further large prospective multicentre studies are needed to further evaluate these initial findings. Factors that were associated with having non-localising 99m Tc-sestamibi scan were right-sided adenomas, superior adenomas and lower preoperative PTH level. Further large prospective multicentre studies are needed to further evaluate these initial findings.A series of electronic push-pull, pull-pull, and push fluorophores has been prepared from a benzoselenadiazole core so that their spectroscopic, electrochemical, spectro-electrochemical, and spectro-electrofluorescence properties could be examined. The emission wavelengths and fluorescence quantum yields (Φfl ) of the N,N-dimethyl fluorophores were contingent on the solvent polarity and they ranged from 615 to 850 nm in aprotic solvents. The positive solvatochromism and the quenched Φfl in polar solvents were consistent with an intramolecular charge-transfer state (ICT). ABT-199 inhibitor Meanwhile, a locally excited state (LE) was assigned in nonpolar solvents from the blue-shifted emission and high Φfl . The N,N-dimethylamine fluorophores examined could be both electrochemically oxidized and reduced, whereas the symmetric dinitro pull-pull derivative could be onl