Christie Le (temperink1)

The proportion of different forms of nitrogen and sulfur in the filler indicated that the removal of ammonia in the LPB mainly depended on the adsorption by moisture, while that in the NPB was microbial degradation, which was also the main removal pathway of sulfur regardless of pH condition. The removal and transformation of different substances in coexisting complex gases showed different characteristics in the LPB and NPB respectively.A hydrodynamic model is applied to a domain encompassing Mosquito Lagoon and a segment of north Indian River Lagoon on the east coast of Florida with the goals of (1) describing the hydrodynamic regime of the area according to existing conditions and (2) to determine the flushing rates of the system after introducing a hypothetical pollutant (numerical dye tracer). Results from the 1-year simulation agree with observations and show that the Mosquito Lagoon (ML) and North Indian River Lagoon (NIRL) are dominated by the nontidal (low frequency) water level oscillations except at the northernmost part of the ML where the influence of tidal renewal dominates. The global tracer application results reveal that only the two northernmost segments of Mosquito Lagoon (ML-ac and ML-df) reach 50% of tracer concentrations (R50) within the year of simulation (day 19 and day 176 respectively). The five (discrete) segments tracer study resulted in lower R50 values and the hypothetical pollutant is removed (flushed) from each of the segments within the year and with an averaged renewal time value for the Mosquito Lagoon basin of 98 days. Observed throughout the simulation period is the interaction across the different segments and a predominantly two-layered water mass exchange through the Haulover Canal. Most significant is that the resulting renewal times (R50) indicate the existence of three dynamically distinct sections within Mosquito Lagoon. These findings aid in the identification of poorly flushed zones and serve as a baseline for the duration and possible propagation of detrimental conditions such as a harmful algal bloom (HAB) event or a contaminant spill.The kappa opioid receptor (KOR) is thought to regulate neural systems associated with anhedonia and aversion and mediate negative affective states that are associated with a number of psychiatric disorders, but especially major depressive disorder (MDD). Largely because KOR antagonists mitigate the effects of stress in preclinical studies, KOR antagonists have been recommended as novel drugs for treating MDD. The purpose of this review is to examine the role of KORs and its endogenous ligand dynorphins (DYNs) in the pathology and treatment of MDD derived from different types of clinical studies. Evidence pertaining to the role of KOR and MDD will be reviewed from (1) post mortem mRNA expression patterns in MDD, (2) the utility of KOR neuroimaging agents and serum biomarkers in MDD, and (3) evidence from the recent Fast Fail clinical trial that established KOR antagonism as a potential therapeutic strategy for the alleviation of anhedonia, a core feature of MDD. These findings are compared with a focused evaluation of stress-induced alterations in OPRK and PDYN mRNA expression. Finally, the current status of the effects of KOR antagonists on behavioral phenotypes of stress in preclinical studies related to MDD is summarized. Stereoelectroencephalography (SEEG) allows the identification of deep-seated seizure foci and determination of the epileptogenic zone (EZ) in drug-resistant epilepsy (DRE) patients. We evaluated the accuracy and treatment-associated morbidity of frameless VarioGuide® (VG) neuronavigation-guided depth electrode (DE) implantations. We retrospectively identified all consecutive adult DRE patients, who underwent VG-neuronavigation DE implantations, between March 2013 and April 2019. Clinical data were extracted from the electronic patient charts. An interdisciplinary team agreed upon all treatment decisions. We pe