Trujillo McPherson (tankerchive6)

Emerging advancements in anticancer drug discovery research are leaning towards the plant-based bioactive fractions, which is a cocktail of naturally abundant two or more substances with unique proportions, exhibiting greater potential to combat cancers than the individual molecules. Thus, isolation and characterization of anti-cancer activity enriched fractions from plants is gaining scientific attention. Consistent with this view, one of the evidence-based traditional medicinal plants, well known for its anti-cancer potential, Simarouba glauca (SG) leaf has been scientifically examined to identify and isolate the potent anti-cancer fraction. The dried SG leaves were extracted successively with the solvents of increasing polarity. The phytochemical characterization of obtained extracts and fractions were carried out to determine the phenolic acid composition. All fractions were individually examined for anti-cancer property in cancer cells representing lungs, cervix, breast, colon and rectum in vitro. Among all fractions tested, the chloroform (SGC) and ethyl acetate (SGEA) extracts showed potent anti-proliferative effects by triggering apoptosis. In summary, our findings demonstrate that the extracts SGC and SGEA have potent anti-cancer activities compared to other fractions of SG leaf and thus warrant further pre-clinical studies to establish scientific basis for the anticancer potentials of SG. © 2020 The Authors.Purpose Mindfulness based interventions (MBIs) are an emerging area of empirical study, not only in positive psychology, but also in clinical health care. This research aims to synthesize the evidence about whether MBIs reduce blood pressure (BP) in patients with non-communicable diseases (NCDs). Methods Relevant studies were identified via PubMed, the Cochrane Library, Embase and the CINAHL database between 2009 and 2019. The papers selected focused on mindfulness and the effect of these on the BP of patients with NCDs. The change in SBP and DBP were meta-analyzed, stratified by type of intervention (Breathing awareness meditation (BAM), Mindfulness Meditation (MM), and Mindfulness-based Stress Reduction (MBSR). Results Fourteen articles met eligibility criteria and were included in the final review. Among the studies using the type and duration of intervention, systolic BP was reduced after the mindfulness-based stress reduction for 8 weeks (-6.90 mmHg [95% CI -10.82, -2.97], p less then .050), followed by the breathing awareness meditation for 12 weeks (-4.10 mmHg [95% CI -7.54, -0.66], p less then .050) and the mindfulness-based intervention for 8 weeks (-2.69 mmHg [95% CI -3.90, -1.49], p less then .050) whereas diastolic BP was reduced after the mindfulness-based stress reduction for 8 weeks (-2.45 mmHg [95% CI -3.74, -1.17], p less then .050) and the mindfulness-based intervention for 8 weeks (-2.24 mmHg [95% CI -3.22, -1.26], p less then .050). Conclusion MBIs can provide effective alternative therapies to assist in blood pressure reduction for patients with NCDs. © 2020 The Author(s).Teleoperation virtual platforms allow people to send their skills and capacities into machines located in either relative close (few meters away) or far (different continents) locations. With the use of lightweight protocols, people can remotely control the actions and movements of robots so they can avoid physical interaction with dangerous or risky places. Oil and gas well-pads stations are working zones considered hazardous due to the various chemical substances used in their daily processes. This characteristic makes these places the perfect candidates for the implementation of teleoperation solutions in order to reduce the direct interaction of humans with different chemicals and risky situations. The following investigation focuses on the development of a base teleoperation scheme to perform inspection and maintenance tasks in the inside one of these hydrocarbon facilities. The proposed system aims to generate an easi