Olsson Hauge (sudancarol4)

Background The best way to administer steroids for sudden sensorineural hearing loss (SSHL) is still unclear. The present study was aimed at estimating the efficacy of steroids by intratympanic, systemic, and combined therapy (CT) routes. Methods A systematic literature search was performed from 1950 to October 2019 for randomized controlled trials comparing the use of intratympanic, systemic, and combined steroid therapy for SSHL. The outcomes of recovery rate and pure tone average (PTA) improvement were assessed by random-effects and fixed-effects meta-analysis. Results A total of 20 articles identified from 7 countries were eligible for analysis. Although no significant difference in recovery rate was observed between intratympanic steroid therapy (IST) and systemic steroid therapy (SST), IST did demonstrate better hearing improvement, as evidenced by a higher PTA than SST. Compared with SST, CT comprising IST and SST had significant recovery rate improvement. Patients treated with CT had a significantly higher PTA than those treated with SST. Through subgroup analysis based on the equivalent dose of prednisone, it was shown that CT led to a significantly higher PTA than SST only in the high-dose CT versus high-dose SST groups and moderate-dose CT versus high-dose SST groups. Conclusion Moderate and high dose of CT could accelerate hearing improvement in SSHL.INTRODUCTION Middle ear pathologies have been linked with HIV. The onset and development of these pathologies in individuals with HIV have not been categorized; and clarity has not been gained regarding whether their presentation is any different in this population when compared to HIV negative control group. PURPOSE The aim of this study was to explore and document published evidence reflecting trends in middle ear pathologies in adults living with HIV. METHODS A systematic review of literature from January 1982 to December 2018 was conducted using Medline, CINAHL, PubMed, and Psych Info. Studies that reported the occurrence rate of middle ear pathologies in adults with HIV and published in English were included. RESULTS Twelve articles met the inclusion criteria. Evidence suggests that the reported occurrence rates of middle ear pathologies ranges from 2.5% to 58% in this population. The variability in assessment measures as well as the different cut-off criteria used in studies seem to have an influence inestablish the time of onset and development of middle ear pathologies is required.Non-experimental designs are common in nursing and allied health research wherein study participants often represent more than a single population or interest. Hence, methods used to identify subgroups and explore heterogeneity have become popular. Latent class mixture modeling is a versatile and person-centered analytic strategy that allows us to study questions about subgroups within samples. In this article, a worked example of latent class mixture modeling is presented to help expose researchers to the nuances of this analytic strategy.Artificial intelligence (AI)-based algorithms are rapidly entering the health care field and have the potential to improve patient care. Our article focuses on the use of autonomous AI algorithms (ie, algorithms that can make clinical decisions without human oversight) in diagnostic imaging. In this article, we have used the example of diabetic retinopathy screening to highlight some important aspects to be considered by developers, policymakers, and end users when bringing autonomous AI algorithms into clinical practice. We have divided these aspects into (1) following the principles of safety, efficacy, and equity in all phases of development and implementation of the algorithm; (2) regulatory processes involving medical records, medical liability, and patient privacy; (3) cost and billing; and (4) the role of health care providers.Endoscope provide the excellent view and observe the entire perforation edges, endoscopic cartilage myringoplasty d