Franklin Boye (stovetext8)

OBJECTIVE To explore the effect of early-onset preeclampsia on the blood pressure of offspring during the first month of life. STUDY DESIGN This prospective case-control study included 106 neonates of mothers with early-onset preeclampsia (developing at less then 34 weeks of gestation) and 106 infants of normotensive mothers, matched 1-to-1 for sex and gestational age. Serial blood pressure measurements were obtained on admission, daily for the first postnatal week, and then weekly up to the fourth week of life. RESULTS There were no differences in blood pressure values on admission and the first day of life between cases and controls. Conversely, infants exposed to preeclampsia had significantly higher systolic (SBP), diastolic (DBP), and mean blood pressure (MBP) on the subsequent days up to the fourth postnatal week (P  less then .001-.033). Multiple regression analyses with adjustment for sex, gestational age, antenatal corticosteroid use, and maternal antihypertensive medication use confirmed the foregoing findings (P  less then .001-.048). Repeated-measures ANOVA also identified preeclampsia as a significant determinant of trends in SBP, DBP, and MBP during the first month of life (F = 16.2, P  less then  .001; F = 16.4, P  less then  .001; and F = 17.7, P  less then  .001, respectively). CONCLUSIONS Infants of mothers with early-onset preeclampsia have elevated blood pressure values throughout the neonatal period compared with infants born to normotensive mothers. OBJECTIVE To adapt the vocal fatigue index (VFI) for the Tamil-speaking population. STUDY DESIGN Cross-sectional research design METHOD VFI developed originally in English was translated in the Tamil language, a South Indian Dravidian language. Content validity and reverse translation of VFI in Tamil [VFI-T] was done. The final of VFI-T was administered on 251 subjects with voice concerns/ problems and on 100 individuals with perceptually normal voice for validity and reliability measures. RESULTS Factor analysis of VFI-T yielded four factors as opposed to three factors in the English version of VFI. The four factors were extracted based on Eigenvalue and variance contributed by each factor namely, I-physical discomfort; II-tiredness of voice and avoidance of voice use; III-increased effort and its effect on voice quality, and IV-Improvement of symptoms with rest. Varimax rotation and factor loading values for individual items identified five items under factor I; seven items under factor II; four items under factor III, and three items were preserved under factor IV. Overall Cronbach's alpha coefficient was 0.91 and alpha values for four factors ranged from 0.75 to 0.85. read more Item-to-total correlation revealed good internal consistency between the items. The median and interquartile range of VFI-T for cases and controls were viz., I-6.00 (10.00); 0.00 (1.00), factor II-12.00 (11.00); 1.00 (3.00), factor III-7.00 (8.00); 1.00 (2.00), and factor IV-6.00 (6.00); 1.00 (3.00), respectively. Mann-Whitney U test revealed a significant difference between the scores of cases and controls (P less then 0.00). Logistic regression suggested sensitivity of 96% and a specificity of 79% for the inventory in the Tamil language. CONCLUSION VFI-T identified and documented vocal fatigue under four factors in subjects with voice disorders. OBJECTIVE Proton pump inhibitors (PPIs) are the fourth most widely sold drugs in the United States. Mounting evidence suggests PPIs may not be as safe as originally thought. We hypothesize that increased awareness of PPI side effects and patient education may influence patient interest in PPI use and compliance. We aimed to investigate patient concerns and education regarding PPI use and side effects. STUDY DESIGN Prospective questionnaire. SETTING Tertiary care center. SUBJECTS AND METHODS Consecutive patients with a diagnosis of gastroesophageal or laryngophar