Pedersen Hammond (spoonash7)

Multiphase microscale emulsions are a material platform that can be tuned and dynamically configured by a variety of chemical and physical phenomena, rendering them inexpensive and broadly programmable optical transducers. Interface engineering underpins many of these sensing schemes but typically focuses on manipulating a single interface, while engineering of the multiphase junctions of complex emulsions remains underexplored. Herein, multiphilic triblock copolymer surfactants are synthesized and assembled at the triphase junction of a dynamically reconfigurable biphasic emulsion. Tailoring the linear structure and composition of the polymer surfactants provides affinity to each phase of the complex emulsion (hydrocarbon, fluorocarbon, and continuous water phase), yielding selective localization of polymers around the triphase junction. Conjugation of these polymers with gold nanoparticles, forming structured rings, affords a dynamic reflected isotropic structural color that tracks with emulsion morphology, demonstrating the uniquely enabling nature of a functionalized triphase interface. This color is the result of interference of light along the internal hydrocarbon/fluorocarbon interface, with the gold nanoparticles scattering and redirecting light into total internal reflection competent paths. Thus, the functionalization of the triphase junction renders complex emulsions colorimetric sensors, a powerful tool toward sensitive and simple sensing platforms.Pulmonary large cell carcinoma (LCC) is classified as a poorly defined entity among non-small cell lung cancers (NSCLCs). At present, there are no effective anticancer drugs, such as molecular targeted drugs, for LCC, and it has been reported that patient prognosis is poor. Recently, the development of immune checkpoint inhibitors (ICIs) has changed the therapeutic strategies for patients with NSCLC. Here, we present a case of LCC successfully treated with pembrolizumab. A 58-year-old man who was a former smoker was diagnosed with LCC. The postoperative stage was T3N2M0. During postoperative adjuvant chemotherapy, swelling of the supraclavicular lymph node was observed and the patient was diagnosed with recurrence. The patient was treated with two regimens of conventional cytotoxic chemotherapy; however, he experienced some hoarseness. Imaging confirmed swelling of the hilar and mediastinal lymph nodes and the patient was subsequently diagnosed with disease progression. Previous surgical specimens when immunostained showed that a high proportion of the tumor cells were positive for expression of programmed death-ligand 1 (PD-L1), and it was decided to commence treatment with pembrolizumab. This treatment resulted in rapid regression of the hilar and mediastinal lymph nodes, and a progression-free period maintained for at least 24 treatment cycles. The patient's hoarseness improved, and the lymph nodes decreased in size. Immunotherapy targeting PD-1/PD-L1 may be an option for patients with PD-L1 positive LCC. This case report suggests that treatment with ICIs may be important in the selection of treatment for not only LCC but also relatively rare NSCLC with high PD-L1 expression. To evaluate the impact of a 12-month multi-modal public health intervention programme for treating and preventing anaemia among children aged 6months to 4years in an underserved community in Peru. The intervention included nutritional education, use of a Lucky Iron Fish cooking tool, and dietary supplementation. The primary outcome measure was anaemia resolution. Secondary outcomes included absolute changes in haemoglobin, change in knowledge survey scores and adherence to interventions. Chi-square test and Mann-Whitney U-test were employed to identify associations between anaemia and intervention-related measures. Variables found to be significantly associated in bivariate analysis or of clinical importance were included in a logistic regression model. Of th