Spivey Cote (spikechurch81)

Two-dimensional volumetric exercise stress echocardiography (ESE) provides an integrated view of left ventricular (LV) preload reserve through end-diastolic volume (EDV) and LV contractile reserve (LVCR) through end-systolic volume (ESV) changes. To assess the dependence of cardiac reserve upon LVCR, EDV, and heart rate (HR) during ESE. We prospectively performed semi-supine bicycle or treadmill ESE in 1344 patients (age 59.8 ± 11.4 years; ejection fraction = 63 ± 8%) referred for known or suspected coronary artery disease. All patients had negative ESE by wall motion criteria. EDV and ESV were measured by biplane Simpson rule with 2-dimensional echocardiography. Cardiac index reserve was identified by peak-rest value. LVCR was the stress-rest ratio of force (systolic blood pressure by cuff sphygmomanometer/ESV, abnormal values ≤2.0). Preload reserve was defined by an increase in EDV. Cardiac index was calculated as stroke volume index * HR (by EKG). HR reserve (stress/rest ratio) <1.85 identified chiac reserve.Several studies have highlighted the diagnostic potential of salivary microRNA (miRNA) in head and neck squamous cell cancer (HNSCC). The purpose of this meta-analysis was to summarize published studies and evaluate the diagnostic accuracy of salivary miRNA in HNSCC detection. In this meta-analysis, we systematically searched PubMed, EMBASE, and Cochrane Library databases for studies on miRNA and HNSCC diagnosis. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) with a summary receiver-operating characteristic curve were calculated using a bivariate random-effect meta-analysis model. Furthermore, subgroup analyses were conducted to explore the main sources of heterogeneity. Seventeen studies from ten articles, including 23 miRNA and a total of 759 subjects, were included in this meta-analysis. The pooled sensitivity and specificity of salivary miRNA in the diagnosis of HNSCC were 0.697 (95% CI 0.644-0.744) and 0.868 (95% CI 0.811-0.910), respectively. The overall area under the curve was 0.803 with a DOR of 12.915 (95% CI 9.512-17.534). Salivary miRNAs are a promising non-invasive diagnostic biomarker with moderate accuracy for HNSCC. These results must be verified by large-scale prospective studies.Sustainable management strategies are needed to improve agronomic efficiency and cereal yield production under harsh abiotic climatic conditions such as in tropical Savannah. Under these environments, field-grown crops are usually exposed to drought and high temperature conditions. Silicon (Si) application could be a useful and sustainable strategy to enhance agronomic N use efficiency, leading to better cereal development. This study was developed to explore the effect of Si application as a soil amendment source (Ca and Mg silicate) associated with N levels applied in a side-dressing (control, low, medium and high N levels) on maize and wheat development, N uptake, agronomic efficiency and grain yield. The field experiments were carried out during four cropping seasons, using two soil amendment sources (Ca and Mg silicate and dolomitic limestone) and four N levels (0, 50, 100 and 200 kg N ha-1). The following evaluations were performed in maize and wheat crops the shoots and roots biomass, total N, N-NO3-, N-NH4+ and Si accumulation in the shoots, roots and grain tissue, leaf chlorophyll index, grain yield and agronomic efficiency. The silicon amendment application enhanced leaf chlorophyll index, agronomic efficiency and N-uptake in maize and wheat plants, benefiting shoots and roots development and leading to a higher grain yield (an increase of 5.2 and 7.6%, respectively). It would be possible to reduce N fertilization in maize from 185-180 to 100 kg N ha-1 while maintaining similar grain yield with Si application. Additionally, Si application would reduce N fertilization in wheat from 195-200 to 100 kg N ha-1. Silicon application could be a key technology for improving plant-