Russell Schwarz (seederdragon46)

Education and training is an area that is critical for communicating the current challenges, developing solutions to accelerate the commercialization of the latest technological advances, and growing the work force in the rapidly expanding sector of regenerative medicine. © 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.African American male youth experience disproportionately higher levels of violence. We examined parental depression among African American mothers and nonresident fathers on parenting stress and school involvement in their adolescent sons' school connectedness and violent behaviors. Using a longitudinal study design, parent factors were assessed when sons were 9 years old on youth outcomes at age 15. We found that maternal depression was associated with maternal stress, and maternal stress was indirectly associated with sons' violent behaviors through school connectedness. School involvement among nonresident fathers was positively associated with sons' school connectedness, which was linked to less youth violent behaviors. Maternal stress and nonresident fathers' school involvement are influential for understanding youth violence. Future interventions should incorporate a more nuanced approach when including family factors. © 2020 Wiley Periodicals, Inc.We demonstrate a mechanochemical route for room-temperature and solvent-free derivatization of different types of amides into carbamoyl-isatins (up to 96% conversion or yield), -benzamides (up to 81% yield) and -imides (up to 92% yield). In solution, this copper-catalyzed coupling either does not take place, or requires high temperatures at which it may also be competing with alternative thermal reactivity, highlighting the beneficial role of mechanochemistry for this reaction. Such behavior resembles the previously investigated coupling with sulfonamide substrates, suggesting this type of C-N coupling is an example of a mechanochemically-favored reaction, for which mechanochemistry appears to be a favored environment over solution. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND & AIMS Current guidelines for chronic hepatitis B (CHB) patients are to undergo surveillance for hepatocellular carcinoma (HCC) with 6-monthly ultrasonography (US). However, sensitivities of US to detect early-stage HCC in cirrhotic patients are suboptimal. We aimed to compare overall survival and detection rates of very-early-stage HCC in 2 groups group A, undergoing 6-monthly US versus group B, undergoing 6-monthly US alternating with dynamic computed tomography (CT). METHODS This retrospective multi-center study assessed 1,235 cirrhotic patients with CHB under entecavir/tenofovir therapy from 2007 to 2016. The primary endpoint was overall survival rates between the two groups. The Cox proportional hazards model and propensity-score matching analyses were used to assess the effect of surveillance modalities on overall survival and detection of BCLC 0 HCC after balancing. RESULTS During a median follow-up of 4.5 years, 10-year cumulative HCC incidence rates of 16.3% were significantly higher in group B (n=576) than 13.7% in group A (n=659; P less then 0.001). However, in patients with HCC, 10-year overall survival rates of 85.1% were significantly higher in group B than 65.6% in group A (P=0.001 by log-rank test). CT exam alternating with US was independently associated with reduced overall mortality (HR 0.47, P=0.02). Ruboxistaurin cell line Cumulative incidence of Barcelona Clinic Liver Cancer stage (BCLC) 0 HCC were significantly higher in group B than in group A (HR 2.82, P less then 0.001). CONCLUSION In cirrhotic patients with CHB, dynamic CT exam alternating with US led to higher detection rates of very-early-stage HCC and benefit of overall survival compared to US exams. This article is protected by copyright. All rights reserved.Papillon-Lefèvre syndrome (PLS) is a rare disorder ch