Shepard Laustsen (sarahline62)

Three-dimensional (3D) planning and patient-specific surgical guides are increasingly used in the treatment of skeletal deformities. The present study hypothesis was that they are reliable in forearm osteotomy in children, with low morbidity. Twenty-there children with one or several osteotomies to correct forearm deformities were retrospectively included 9 (20 osteotomies) with surgical guide (G+), and 14 (28 osteotomies) without (G-). Etiologies comprised 8 cases of Madelung disease (3G+, 5G-) and 15 of post-traumatic malunion (6G+, 9G-). Mean age at surgery was 14.8±1.9 years. The patient-specific 3D-printed polyamide guides were produced from 3D virtual models based on 3D CT reconstruction. Mean follow-up was 22.1±13.6 months. Mean correction error was 5.3°±4.1 and 4.2°±4.1 in the frontal and sagittal planes respectively in G+ (p=0.6). Surgery time was significantly shorter in G+, by a mean 42min (p=0.02). Mean total radiation dose (preoperative CT+intraoperative fluoroscopy) was significantly higher in G+ (p<0.0001). Complications rates were similar between groups. Improvement in PRWE score was significantly greater in G+. The present preliminary results were encouraging. 3D planning and patient-specific surgical guides can be used in the treatment of forearm deformity in children. III; retrospective cohort study. III; retrospective cohort study.We present a new arthroplasty concept for the first metatarsophalangeal joint (MTP1) involving the HAPY® pyrocarbon interposition implant. This is a spherical implant that does not integrate into bone. Instead, the goal is to achieve gliding of the implant on the bone/cartilage to maintain the function and mobility of the MTP1 joint. We describe the surgical technique used for its implantation. Since the implant is not anchored into bone, it is stabilized in a spherical cavity hollowed out in the metatarsal head. In a preliminary study of 22 cases with a mean follow-up of 36 (20-79) months, the mean AOFAS score improved from 64 (35-72) preoperatively to 91 (47-100) postoperatively (p less then 0.05). At the final assessment, no subchondral cyst or osteolysis was visible.Chronic pain is a major health care problem. A better mechanistic understanding and new treatment approaches are urgently needed. In the brain, pain has been associated with neural oscillations at alpha and gamma frequencies, which can be targeted using transcranial alternating current stimulation (tACS). Thus, we investigated the potential of tACS to modulate pain and pain-related autonomic activity in an experimental model of chronic pain in 29 healthy participants. In 6 recording sessions, participants completed a tonic heat pain paradigm and simultaneously received tACS over prefrontal or somatosensory cortices at alpha or gamma frequencies or sham tACS. Concurrently, pain ratings and autonomic responses were collected. Using the present setup, tACS did not modulate pain or autonomic responses. Bayesian statistics confirmed a lack of tACS effects in most conditions. The only exception was alpha tACS over somatosensory cortex where evidence was inconclusive. Taken together, we did not find significant tACS effects on tonic experimental pain in healthy humans. Based on our present and previous findings, further studies might apply refined stimulation protocols targeting somatosensory alpha oscillations. TRIAL REGISTRATION The study protocol was pre-registered at ClinicalTrials.gov (NCT03805854). PERSPECTIVE Modulating brain oscillations is a promising approach for the treatment of pain. We therefore applied transcranial alternating current stimulation (tACS) to modulate experimental pain in healthy participants. However, tACS did not modulate pain, autonomic responses, or EEG oscillations. These findings help to shape future tACS studies for the treatment of pain.Acetoin is widely used in food and cosmetics industries as a taste and fragrance enhancer. To