Coates Klint (rosesalmon11)

As animal models play a key role in exploring the pathophysiology of disease, our findings provide strong support for the study of lymphedema. The irreversibility of fibrosis suggests the importance of treating lymphedema by preventing fibrosis development. IJCEP Copyright © 2020.BACKGROUND Gastrointestinal stromal tumor (GIST) of the small bowel is a rare malignancy and accounts for only 0.1-3% of all gastrointestinal neoplasms. GISTs may mimic gynecologic tumors. The authors present an unusual case of ruptured jejunal GIST with hemoperitoneum mimicking ovarian carcinoma. CASE PRESENTATION A 57-year-old postmenopausal woman presented with progressive, generalized low abdominal pain for 3 months. Computed tomography (CT) imaging depicted a 9.6 cm-sized, complex and solid mass on the left pelvic cavity and a 3.7 cm-sized heterogeneous, enhancing mass on the right adnexa, suspicious for ovarian cancer accompanied by hemoperitoneum. There was no active bleeding. Laboratory examination revealed a low level of serum hemoglobin (6.7 g/dL), and a raised serum level of CA-125 (107.0 U/mL). Based on CT imaging findings and an elevated serum level of CA-125, bilateral ovarian cancer was suspected. The patient underwent exploratory laparotomy, and frozen section of the excised mass indicated malignancy originating from the small bowel jejunum. Consequently, small bowel segmental resection with mesenteric resection was done, and a debulking operation including hysterectomy, BSO, BPLD, omentectomy, and excision of multiple metastatic masses in the peritoneum was performed. Subsequent histopathologic examination confirmed the final diagnosis of high risk GISTs of the primary small bowel jejunum. The patient's postoperative course was uneventful, and adjuvant Imatinib was administered. CONCLUSION The authors report an unusual case of ruptured jejunal GIST with hemoperitoneum mimicking ovarian carcinoma. Therefore, GIST, in addition to ovarian cancer, should be considered in patients with an increased serum level of CA-125 and an abdominopelvic mass. IJCEP Copyright © 2020.Intraoperative pathologic diagnosis for central nervous system (CNS) tumors is important to determine the neurosurgery procedure. But sometimes the differential diagnosis between glioma and lymphoma, or glioma and metastatic tumors is difficult for a pathologist during a short time, especially when the specimen is small or the frozen section has ice crystals. check details Immunohistochemistry (IHC) is a very useful method for diagnosis, but the traditional immunohistochemical method is time-consuming and not suitable intraoperatively. In this study, we chose Cytokeratin-pan, GFAP, and LCA as three immunohistochemical indicators. Intraoperative IHC was done by Novodiax ihcDirect technology combined with Leica Bond auto-staining. Compared with the manual method recommended for the reagents (Novodiax ihcDirect), the results show that auto-staining has better stability and high reproducibility in coloration, which has broad prospects for future application. IJCEP Copyright © 2020.BACKGROUND We studied the clinicopathologic features of superficial CD34-positive fibroblastic tumor (SCPFT), which is a newly described neoplasm, to enhance the recognition and diagnostic level of the disease. CASE PRESENTATION We herein report two cases of superficial CD34-positive fibroblastic tumors in a 33-year-old man and a 30-year-old man. The 33-year-old man presented with a slow-growing subcutaneous nodule 5.0 cm in diameter on the right thigh, and the 30-year-old man developed a painful lump 4.0 cm in diameter on his right thigh. Histologically, the tumor was located in superficial soft tissue with relative circumscription. Tumors had abundant spindled polygonal cells, which were arranged in fascicular or sheet-like patterns. Neoplastic cells were characterized by polymorphic nuclei, granular cytoplasm, intranuclear cytoplasmic pseudoinclusions, and an extremely low mitotic rate. Immunoh