Britt Lohse (recordclose1)

https//github.com/SunjooBang/Polypharmacy-side-effect-prediction. https//github.com/SunjooBang/Polypharmacy-side-effect-prediction. Idiopathic inflammatory myopathies (IIM) cause proximal muscle weakness, which affect activities of daily living. Wearable physical activity monitors (PAMs) objectively assess continuous activity with potential clinical usefulness in IIM assessment. We examined the psychometric characteristics for PAM outcomes in IIM. Adult IIM patients were prospectively evaluated (baseline, 3 and 6-months) in an observational study. A waist-worn PAM (ActiGraph GT3X-BT) assessed average step counts/min, peak 1-min cadence, and vector magnitude/min. Validated myositis core set measures (CSM) including manual muscle testing (MMT), physician global disease activity (MD global), patient global disease activity (Pt global), extra-muscular disease activity (Ex-muscular global), HAQ-DI, muscle enzymes, and patient-reported physical function were evaluated. Test-retest reliability, construct validity, and responsiveness were determined for PAM measures and CSM using Pearson correlations and other appropriate analyses. 50 adultnsiveness; especially peak 1-min cadence. PAMs provide valid outcome measures for future use in IIM clinical trials. In tundra systems, soil-borne lichens are often the dominant groundcover organisms, and act to buffer microclimate extremes within or at the surface of the soil. However, shrubs are currently expanding across tundra systems, potentially causing major shifts in the microclimate landscape. Here, we compared soil temperature and moisture underneath the dwarf birch Betula nana and seven abundant lichen species in subalpine Norway. We also examined mixtures of lichens and dwarf birch, an intermediate phase of shrubification, and measured several functional traits relating to microclimate. We found that all lichen species strongly buffered the daily temperature range, on average reducing maximum temperatures by 6.9 °C (± 0.7 SD) and increasing minimum temperatures by 1.0 °C (± 0.2 SD) during summer. The dwarf birch had a much weaker effect (maximum reduced by 2.4 °C ± 5.0 SD and minimum raised by 0.2 °C ± 0.9 SD). In species mixtures, the lichen effect predominated, affecting temperature extremes by more than would be expected from their abundance. Lichens also tended to reduce soil moisture, which could be explained by their ability to intercept rainfall. Our trait measurements under laboratory conditions suggest that, on average, lichens can completely absorb a 4.09mm (± 1.81 SD) rainfall event, which might be an underappreciated part of lichen-vascular plant competition in areas where summer rainfall events are small. In the context of shrubification across tundra systems, our findings suggest that lichens will continue to have a large effect on microclimate until they are fully excluded, at which point microclimate extremes will increase greatly. In the context of shrubification across tundra systems, our findings suggest that lichens will continue to have a large effect on microclimate until they are fully excluded, at which point microclimate extremes will increase greatly.William Costerton, the pioneer of bacterial biofilm research and Wilson published a review of this subject in 2012. Recent events and false claims have prompted an update for urologists regarding the science of penile implant biofilm. The recent biofilm literature has been investigated and new conclusions regarding penile implant biofilm physiology are clarified in this review. The timeline of biofilm formation is as follows. The wound is contaminated upon incision, and the inoculum of bacteria ceases with incision closure. Almost immediately planktonic bacteria attach to the implant and secrete biofilm which alters the host's ability to eradicate the bacteria. Infection retardant coatings impair clinical infection by common skin org