McWilliams Goodman (pullbridge3)

individuals deciding to undergo WB-MRI for early cancer diagnosis. Scope exists for measures to assess expected feelings and develop personalized interventions to reduce the stress anticipated by individuals deciding to undergo WB-MRI for early cancer diagnosis. To evaluate the influence of exomass-related metal artefacts on the detection of simulated vertical root fracture (VRF) in cone-beam computed tomography (CBCT). 20 teeth were endodontically instrumented and VRF was induced in half of them. All teeth were individually placed in an empty socket of a human mandible. Metallic materials were differently arranged in the exomass [zone outside of the field of view (FOV) but between the X-ray source and the receptor] and/or endomass (zone inside of the FOV), and CBCT scans were obtained. Four radiologists evaluated the presence of VRF using a 5-point scale. Sensitivity, specificity, and area under the receiver operating curve (AUC) were compared using ANOVA. Also, the tooth of interest was replaced with a tube filled with a radiopaque solution and all CBCT scans were repeated to analyse the data objectively. Mean grey and noise values were obtained from the tube and compared using ANOVA followed by Tukey's test (α = 0.05). Mean grey values were significantly lower and noise was significantly higher when metallic materials were present in the endomass or both the exomass and endomass. Sensitivity, specificity, and AUC were not influenced by the artefacts from the metallic materials irrespective of the arrangement condition. Exomass-related metal artefacts did not influence the diagnosis of simulated VRF in CBCT. Exomass-related metal artefacts did not influence the diagnosis of simulated VRF in CBCT.We present a first-time study on identifying the causes and remedies to Nigeria's low contribution to globally recognized research literature. A mixed research approach involving 300 academic staff from several areas of specialization in southern Nigeria was adopted, using structured questionnaire and semi-structured interview schedule. Data obtained were analyzed using descriptive statistics and thematic technique. Furthermore, 43.7%, 28.6%, and 27.7% of the respondents were from the university, polytechnic, and college of education system, respectively. While 78.4% of the respondents agreed that the high cost of open access publication in top journals influenced Nigeria's low contribution to research literature, over 75% reported that the low contribution was due to high cost of attending international conferences. Other factors identified were stringent conditions for paper acceptance (89.7%), scarcity of relevant information about Africa (85.4%), and paucity of high-impact journals in the libraries of Nigerian tertiary institutions (6.7%). Others were poor funding, non-usage of research findings by policymakers, lack of adequate facilities, and high penchant for publication in predatory journals, informed by promotion criteria not supportive of quality. Participants advocated for increased funding, reduced conference fees, and entrenchment of collaboration between reputable publishers abroad and African publishers.Autophagy has been implicated in neurodegenerative diseases. Forkhead box O3 (FoxO3) transcription factors promote autophagy in heart and inhibit oxidative damage. Here we investigate the role of FoxO3 transcription factors in regulating autophagy after oxidative stress injury in immortalized mouse hippocampal cell line (HT22). The present study confirms that hydrogen peroxide (H2O2) injury could induce autophagy and FoxO3 activation in HT22 cells. In addition, overexpression of FoxO3 enhanced H2O2-induced autophagy activation and suppressed neuronal cell damage, while knockdown of FoxO3 reduced H2O2-induced autophagy activation and exacerbated neuronal cell injury. Inhibition of autophagy by 3-Methyladenine (3-MA) resulted in reduced cell viability, increased produc