Hays Corcoran (pigroof1)

Orthostatic hypotension (OH) is defined as an abnormal blood pressure reduction when standing and is frequently diagnosed in older adults. Pharmacological therapy is one of the main causes of orthostatic blood pressure impairment, leading to iatrogenic OH. Indeed, several medications may induce hypotensive effects and influence the blood pressure response to orthostatism. Hypotensive medications may also overlap with other determinants of OH, thus increasing the burden of symptoms and the risk of complications. Potentially hypotensive medications include both cardiovascular and psychoactive drugs, which are frequently prescribed in older patients. According to the available evidence, the antihypertensive treatment "per se" does not seem to predispose to OH, even if a higher risk is associated with polypharmacy and drug classes such as with diuretics and vasodilators. As concerns psychoactive medications, OH is a well-known adverse effect of tricyclic antidepressants, trazodone and antipsychotics. The knowledge of hemodynamic consequences of drug therapy may be helpful to improve OH treatment. A medication review is advisable in all patients presenting with OH, particularly at advanced age, aiming at optimizing medical treatment with a view to minimize the risk of iatrogenic OH.Cardiac rehabilitation (CR) is a comprehensive multidisciplinary program individually tailored to the needs of patients with cardiovascular disease. Cardiovascular disease is prevalent in older adults and is the leading cause of death and major disability in adults ≥75 years of age. The mean age of patients eligible for CR is increasing, with greater complexity and specific geriatric features, such as multimorbidity, frailty, and disability. In this population, CR interventions should be aimed to prevent disability and preserve the residual functional capacity. Every patient should be assessed with a multidimensional evaluation that includes clinical, functional, emotional, cognitive and social domains. Exercise-based CR programs have shown to be effective in improving function and quality of life, by reducing disability and age-related deconditioning and contributing favorably to improved health outcomes in an aged population. Very old and frail patients seem to get an even greater potential benefit, and an early start after an acute event can prevent the post-hospital syndrome. Despite these proven benefits, CR is often underused in this population and a great effort should be done to encourage them to attend these programs. There are just a few studies about CR programs in very old and frail patients, therefore a future goal should be to fill this gap.Wound healing is a highly ordered biological process involving a variety of cells, fluids, and molecules. Any obstacles in the link may cause poor wound healing and even the formation of chronic wounds. In recent years, more and more studies have reported that hydrogen peroxide plays an important role in wound healing and throughout the whole process of wound healing. This article reviews the research progress of hydrogen peroxide and literatures in the related fields to provide new ideas and clues for promoting the basic and clinical research of wound healing.As a stressor, burn not only causes physical damage to the patient, but also causes depression and anxiety, which is not conducive to the rehabilitation and restoration of normal life of the patient. The results of studies on the incidence of depression and anxiety disorders in burn patients are different, and the possible pathogenesis remains to be studied. Whether the screening scales of depression and anxiety disorders that are suitable for the general population are equally suitable for burn patients remains questionable. The efficacy of non-pharmaceutical therapy for depression and anxiety disorders in burn patients remains to be studied. This article reviews the possib