Daugaard Cohen (pestfish2)

Materials that combine magnetic order with other desirable physical attributes could find transformative applications in spintronics, quantum sensing, low-density magnets and gas separations. Among potential multifunctional magnetic materials, metal-organic frameworks, in particular, bear structures that offer intrinsic porosity, vast chemical and structural programmability, and the tunability of electronic properties. Nevertheless, magnetic order within metal-organic frameworks has generally been limited to low temperatures, owing largely to challenges in creating a strong magnetic exchange. Here we employ the phenomenon of itinerant ferromagnetism to realize magnetic ordering at TC = 225 K in a mixed-valence chromium(II/III) triazolate compound, which represents the highest ferromagnetic ordering temperature yet observed in a metal-organic framework. The itinerant ferromagnetism proceeds through a double-exchange mechanism, which results in a barrierless charge transport below the Curie temperature and a large negative magnetoresistance of 23% at 5 K. These observations suggest applications for double-exchange-based coordination solids in the emergent fields of magnetoelectrics and spintronics.Enabling the cellular delivery and cytosolic bioavailability of functional proteins constitutes a major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich peptide additives can enhance the cellular uptake of protein-CPP conjugates in a non-endocytic mode, even at low micromolar concentration. We show that such thiol- or HaloTag-reactive additives can result in covalently anchored CPPs on the cell surface, which are highly effective at co-delivering protein cargoes. Taking advantage of the thiol reactivity of our most effective CPP additive, we show that Cys-containing proteins can be readily delivered into the cytosol by simple co-addition of a slight excess of this CPP. Furthermore, we demonstrate the application of our 'CPP-additive technique' in the delivery of functional enzymes, nanobodies and full-length immunoglobulin-G antibodies. This new cellular uptake protocol greatly simplifies both the accessibility and efficiency of protein and antibody delivery, with minimal chemical or genetic engineering.Fascinating phenomena can occur as charge and/or energy carriers are confined in one dimension1-4. One such example is the divergent thermal conductivity (κ) of one-dimensional lattices, even in the presence of anharmonic interatomic interactions-a direct consequence of the Fermi-Pasta-Ulam-Tsingou paradox proposed in 19555. This length dependence of κ, also known as superdiffusive phonon transport, presents a classical anomaly of continued interest6-9. So far the concept has remained purely theoretical, because isolated single atomic chains of sufficient length have been experimentally unattainable. Here we report on the observation of a length-dependent κ extending over 42.5 µm at room temperature for ultrathin van der Waals crystal NbSe3 nanowires. We found that κ follows a 1/3 power law with wire length, which provides experimental evidence pointing towards superdiffusive phonon transport. Contrary to the classical size effect due to phonon-boundary scattering, the observed κ shows a 25-fold enhancement as the characteristic size of the nanowires decreases from 26 to 6.8 nm while displaying a normal-superdiffusive transition. Our analysis indicates that these intriguing observations stem from the transport of one-dimensional phonons excited as a result of elastic stiffening with a fivefold enhancement of Young's modulus. The persistent divergent trend of the observed thermal conductivity with sample length reveals a real possibility of creating novel van der Waals crystal-based thermal superconductors with κ values higher than those of any known materials.In cancer, linking epigenetic alterations to drivers of transformation has been difficult, in part because DNA methylation analyses must cap