Abrams Frederiksen (peanutvest3)

A noteworthy level of variability is seen in the cognitive and functional capacities of people with Alzheimer's disease pathology (ADP). Though a substantial portion of individuals demonstrate considerable impairments in these abilities, a significant number demonstrate little or no deficit. The factors responsible for this disparity are poorly understood. Significant research suggests a positive association between educational achievement and reduced cognitive problems in people affected by ADP. Even though higher educational levels could potentially be linked to functional impairments among those with ADP, this remains a question requiring further investigation. Using 410 AA individuals with elevated pTau181 levels (a biomarker for ADP; defined as log 10 (pTau181) exceeding one standard deviation above the mean), we investigated the effect of educational attainment (categorized as low or high based on 8 years or more of education, respectively) on functional resilience and whether this influence differs between APOE 4 carriers and non-carriers. To quantify functional difficulties, we created a composite score (CDR-FUNC) derived from the four non-memory aspects of the Clinical Dementia Rating (CDR), with values ranging from 0 (no impairment) to 12 (severe). To determine the relationship of EA and CDR-FUNC, a non-parametric Mann-Whitney U test was performed on individuals with advanced pTau181. The results highlighted a correlation between elevated EA levels and improved resilience to functional difficulties among AA individuals with advanced pTau181, as those with higher EA scores exhibited better functional abilities compared to those with lower scores (W=7305, p=0.00007). Our study further indicated that high EA had a stronger impact on functional resilience in the group of four non-carriers, compared to the four carriers (W=5555, p=0.0022). This research investigates the impact of cognitive reserve and EA on functional performance, emphasizing that cognitive reserve shapes the relationship between ADP burden and functional limitations. Surprisingly, this protective influence seems less pronounced among those carrying the significant genetic risk allele 4. Breast cancer (BC) is one of the most widespread forms of cancer affecting women, requiring ongoing medical attention and innovative therapies. A substantial proportion, up to 80%, of breast cancer survivors treated with chemotherapy develop chemotherapy-induced neuropathy (CIN), leading to deterioration in motor control, sensory functions, and quality of life. Numbness, tingling, and/or burning sensations in the extremities, neuromotor control deficits, and an increased risk of falls are all symptoms of CIN. Physical activity (PA) and music-based medicine (MBM) present encouraging paths towards alleviating sensorimotor symptoms. Subsequently, we put forth the notion that the synergistic effects of musical and auditory therapies can be harnessed through Neurologic Dance Training (NDT), implemented with partnered Adapted Tango (NDT-Tango). We will evaluate the impact of NDT-Tango versus home exercise (HEX) on biomechanically measured outcomes. We predict that eight weeks of NDT-Tango practice will produce greater improvements in postural and gait dynamics in comparison to eight weeks of HEX training. This single-center, prospective, two-arm randomized controlled trial randomly assigned participants (ratio 1:11) to either the experimental NDT-Tango intervention or the active control HEX intervention group. The primary endpoints for posture and gait assessment are the changes observed from baseline to after the intervention. Outcomes are gathered at four distinct time points: baseline, midpoint, immediately after the intervention, one month after the intervention, and six months after the intervention. Clinical and biomechanical function tests, along with questionnaires, serve as secondary and tertiary outcome measures, supplementing primary outcome data. Linear