Jefferson Pena (paradechair2)

Artemisinin compounds have shown satisfactory safety records in anti-malarial clinical practice over decades and have revealed value as inexpensive anti-tumor adjuvant chemotherapeutic drugs. However, the rational design and precise preparation of nanomedicines based on the artemisinin drugs are still limited due to their non-aromatic and fragile chemical structure. Herein, a bioinspired coordination-driven self-assembly strategy was developed to manufacture the artemisinin-based nanoprodrug with a significantly increased drug loading efficacy (∼70 wt %) and decreased preparation complexity compared to conventional nanodrugs. The nanoprodrug has suitable size distribution and robust colloidal stability for cancer targeting in vivo. The nanoprodrug was able to quickly disassemble in the tumor microenvironment with weak acidity and a high glutathione concentration, which guarantees a better tumor inhibitory effect than direct administration and fewer side effects on normal tissues in vivo. This work highlights a new strategy to harness a robust, simplified, organic solvent-free, and highly repeatable route for nanoprodrug manufacturing, which may offer opportunities to develop cost-effective, safe, and clinically available nanomedicines.The sluggish layered structural sodium reaction kinetics and the easy restacking property are major obstacles hindering the practical application of MoS2-based electrodes for sodium storage. Herein, covalently assembled two-phase MoS2-SnS supported by a hierarchical graphitic carbon nitride/graphene (MoS2-SnS@g-C3N4/G) composite is constructed to improve cycling cyclability and rate performances for Na storage. The multiphase MoS2-SnS@g-C3N4/G is featured with a covalent assembly strategy and an interconnected network architecture. This unique structural design can not only enhance the conductivity and facilitate fast interfacial electron transport, which is confirmed by experiments and density functional theory, but also buffer the volumetric changes of MoS2-SnS. As a result, the as-obtained MoS2-SnS@g-C3N4/G anode delivers a high reversible capacity of 834 mA h g-1 at 0.1 A g-1, a high rate capability of 452 mA h g-1 at 5 A g-1, and a long-term cycling stability (320 mA h g-1 at 2 A g-1 with 54.7% retention after 500 cycles) for the Na half-cell. Coupling with activated carbon (AC), our MoS2-SnS@g-C3N4/G||AC sodium-ion hybrid capacitor delivers high energy/power densities (193.1 W h kg-1/90 W kg-1 and 41.5 W h kg-1/18,000 W kg-1) and a stable cycle life in the potential range of 0-4.0 V. Retromuscular mesh hernia repair using Rives-Stoppa technique has demonstrated the best results when it comes to repairing large midline hernias. We present the first pediatric case successfully treated with this technique. This is the case of a 9-year-old male patient with hernia following urgent midline laparotomy. Basic repair principles included opening of the hernia sac and adhesiolysis, longitudinal incision on the posterior sheath of the rectus muscle and division of the retromuscular space, closure of the posterior sheath, placement of a mesh on this plane in the brand-new retromuscular space, and tension-free closure of the anterior musculo-aponeurotic flap, thus reconstructing the midline. No recurrences have been noted after a 2-year follow-up. Rives-Stoppa technique allows for a more anatomical layered reconstruction, which helps restore the anatomical and physiological properties of the abdominal wall. Fisogatinib In our view, this could be a useful alternative for pediatric hernia treatment. Rives-Stoppa technique allows for a more anatomical layered reconstruction, which helps restore the anatomical and physiological properties of the abdominal wall. In our view, this could be a useful alternative for pediatric hernia treatment.Polyorchidism or testicular duplication is defined as the histologically confirmed presence of more than two testes. This is the cas