Straarup Madsen (pantryturtle7)

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor originated from neural crest cells with the potential for recurrence and metastasis. The peak age for the disease is during the first year after birth. The current therapy is primarily surgery. The patient reported here is the first case of MNTI treated with metformin. A case of a 4-month-old infant with a history of swelling in the mouth for 1 month. The tumor was diagnosed using radiology, pathology, and immunohistochemistry, and it was performed with complete surgical resection. Unfortunately, the tumor recurred 3 months after surgery. We prescribed metformin for the infant. Currently, after 9 months of treatment, the tumor is well controlled without apparent side effects. The case presented suggested that metformin may be an underlying therapy for MNTI. The case presented suggested that metformin may be an underlying therapy for MNTI. We assessd the long-term outcomes from a large prospective cohort of men diagnosed with prostate cancer managed with active surveillance and determined the clinical prognostic factors that may predict the risk of metastases. We retrospectively reviewed data of men enrolled on active surveillance at our institution between 1990 and 2018 with low or intermediate risk disease (stage cT1-2, prostate specific antigen less than 20 ng/ml, and biopsy Grade Group [GG]1-2). Patients were classified into 3 groups by diagnostic GG and prostate specific antigen density. Primary outcome was metastatic prostate cancer detected on imaging or at prostatectomy. In addition, upgrade at surveillance biopsy, active treatment, and overall and prostate cancer specific survival outcomes were assessed. Cox proportional hazards regression models were used. A total of 1,450 men met the inclusion criteria. CW069 Median followup was 77 months (IQR 49-114). The 7-year metastasis-free survival rate was 99%. Metastases developed in 15 men a velocity, and characteristics on multiparametric magnetic resonance imaging should be considered when selecting and counseling patients for active surveillance.Fin kinematics is the key to thrust generation of oscillatory pectoral fins of manta rays. This could be one of the main reasons that fin designs of robotic manta rays are becoming more complex to simulate the fin kinematics more closely so as to generate high thrusts. However, as the trend suggests, the extent of improvement to thrust generation might not be worth the complexities added to the designs. Out-of-the-box design changes that favor the simplicity and yet improve the fin performance can be a sound replicate for the complicated fin design features. One aspect of manta rays' pectoral fins that influences the fin kinematics is the constraint imposed on the movement of their particularly long root chord that is entirely attached to the body of manta rays. Hypothetically, reducing such a constraint can promote the angle-of-attack during flapping, which can improve thrust generation. This paper aims to study if the simple idea of disengagement of the fin root chord from the body, which is obviously a deviation from the nature, can improve thrust generation. An experiment was conducted on thrust generation of four basic fin designs, where different portions of their chord was disengaged from the body step-by-step. The disengagement occurred for each quarter of the chord, starting from the trailing edge towards the leading edge. It was found that the fins with free root chord (minimal attachment to the body) could generate thrust slightly less than the fully constrained fins (full attachment). In addition, it was shown that thrust generation efficiency kept increasing while disengaging the chord further, and reached the maximum for free root chord. This may show that a more efficient and yet powerful fin can be produced with such a deviation from the nature.Aerobic