Bernstein Tran (pagesnail6)
Q960 high-strength steel is widely used in pressure vessels, bridges, offshore platforms and other important steel structural components because of its high strength and good plastic toughness, but alloy elements added to this kind of steel have strong hardenability, especially after welding, so the strength and toughness cannot meet the requirements, which limits its application in a wider range. In this paper, from the point of view of the metallurgical treatment of the weld, the goal is to improve the strength and toughness of the Q960 high strength steel weld metal In order to analyze the influence of Zr on the welding process of Q960 steel and the strengthening and toughening effect of weld metal, this paper takes Fe-Mn-Mo-Cr-Ni as the main alloy system, BaF2-CaF2-Al-Mg as the basic slag system, and adopts the method of melting consumable electrode self-shielded for welding, and analyzes the welding process, microstructure, tensile property and impact toughness of the welded joint. The experimental results show that when the weld metal contains 0.0061% Zr, the minimum spatter rate is only 7%, the maximum slag removal rate is 95%, the maximum hardness is 357HV, the maximum elongation is 34%, and the impact toughness is the highest. At this time, the acicular ferrite content in the weld microstructure is the highest, and there is a certain amount of equiaxed fine-grained ferrite, and the content of proeutectoid ferrite is the least, which effectively improves the strength and toughness of the weld metal.In recent years, microalgae have drawn increasing attention as a valuable source of functional food ingredients. Intriguingly, Nitzschia laevis is rich in fucoxanthinol that is seldom found in natural sources. Fucoxanthinol, a marine xanthophyll carotenoid, possesses various beneficial bioactivities. Nevertheless, it's not clear whether fucoxanthinol could exert anti-neuroinflammatory function. In light of these premises, the aim of the present study was to investigate the anti-inflammatory role of fucoxanthinol purified from Nitzschia laevis in Lipopolysaccharide (LPS)-stimulated microglia. The results showed that pre-treatment of fucoxanthinol remarkably attenuated the expression of LPS-induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and the production of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE-2), nitric oxide (NO) and reactive oxygen species (ROS) induction. Modulation mechanism studies revealed that fucoxanthinol hampered nuclear factor-kappa B (NF-κB), Akt, and mitogen-activated protein kinase (MAPK) pathways. Meanwhile, fucoxanthinol led to the enhancement of nuclear translocation of NF-E2-related factor 2 (Nrf2), and the upregulation of heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO-1). Taken together, the results indicated that fucoxanthinol obtained from Nitzschia laevis had great potential as a neuroprotective agent in neuroinflammation and neurodegenerative disorders.This pilot study investigated factors influencing the application of connected health (CH) in Taiwanese remote areas. These factors cover issues of cost, infrastructure, technology, business sustainability, business model, collaboration, and communication. It aimed to explore the significance and to assess the feasibility of researching CH in Taiwan. A qualitative exploratory study was conducted by interviewing relevant stakeholders (n = 18). The majority were healthcare providers as most of them are the CH end users. Their feedback was essential in reflecting the effectiveness of CH products and services. Therefore, understanding their views is significant in the design of a successful and user-friendly interactive system. A theoretical framework on the introduction of innovations in healthcare was employed to guide data collection and thematic analysis. Additionally, stakeholders proposed strategies for enhancing the implementation of CH
