McDonald Head (magicgrey3)

9 patients. A lower phase angle did increase the odds of severe COVID-19. We believe that factors other than body composition play a more critical role in the development of severe COVID-19. The present systematic review and meta-analysis were conducted to investigate the effects of capsinoids and fermented red pepper paste (FRPP) supplementation on Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP). Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. All randomized clinical trials investigating the effect of capsinoids and FRPP supplementation on blood pressure including SBP and DBP were included. Out of 335 citations, 7 trials that enrolled 363 subjects were included. Capsinoids and FRPP resulted in significant reduction in DBP (Weighted mean differences (WMD)-1.90mmHg; 95% CI,-3.72 to-0.09, P=0.04) but no significant change in SBP (WMD 0.55mmHg, 95% CI-1.45, 2.55, P=0.588). FRPP had a significant reduction in SBP. GSK J4 mw Greater effects on SBP were detected in trials, lasted ≥12 weeks, and sample size >50. Capsinoids with dosage ≤200 and FRPP with dosage of 11.9g significantly decreased DBP. Overall, these data suggest that supplementation with FRPP may play a role in improving SBP and DBP but for capsinoids no effects detected in this analysis on SBP and DBP. Overall, these data suggest that supplementation with FRPP may play a role in improving SBP and DBP but for capsinoids no effects detected in this analysis on SBP and DBP. Ovarian cancer is a lethal disease with few modifiable risk factors. Circulating zinc and copper are potential biomarkers for ovarian cancer; however, evidence of their causal effects are scarce. This study aimed to examine the impact of circulating zinc and copper concentrations on ovarian cancer risk, using meta-analysis and Mendelian randomization (MR) approaches. Twenty case-control studies, including 699 patients with ovarian cancer, 567 patients with benign ovarian lesions, and 1194 healthy controls, were selected for meta-analysis. With a Two-sample MR approach, genetic instruments of 21 single nucleotide polymorphisms (SNPs) associated with circulating zinc and 25 SNPs associated with circulating copper were created. Their genetic associations with ovarian cancer were extracted from a genome-wide association study of 25,509 ovarian cancer cases and 40,941 controls. Ovarian cancer patients had significantly lower concentrations of circulating zinc than healthy controls (Standardized mean differences [SMD]=-1.01, 95% CI-1.38 to-0.64). In contrast, circulating copper concentrations were significantly higher in ovarian cancer patients (SMD=1.46, 95% CI 0.82 to 2.09). In MR analysis, we only found increased circulating zinc concentration causally associated with a lower risk of ovarian cancer (odds ratio=0.968, 95% CI 0.941 to 0.995, per SD of ranked-inverse normalized concentration), especially in the high-grade serous subtype. Although increased circulating copper and decreased zinc concentrations were found in ovarian cancer patients, a suggestive causal association was only detected with zinc concentration, suggesting further studies on zinc interventions for ovarian cancer might have clinical impact. Although increased circulating copper and decreased zinc concentrations were found in ovarian cancer patients, a suggestive causal association was only detected with zinc concentration, suggesting further studies on zinc interventions for ovarian cancer might have clinical impact. The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed. Three subject gr