Hanson Haley (lunchpasta1)

Neighborhood disadvantage is commonly hypothesized to be positively associated with intimate partner violence (IPV) against women. However, longitudinal investigation of this association has been limited, with no studies on whether the timing of exposure matters. We used data from 2,115 women in the UK-based Avon Longitudinal Study of Parents and Children. Exposure to neighborhood-level deprivation was measured at 10-time points from baseline (gestation) until age 18. Family-level socioeconomic characteristics were measured at baseline. At age 21, participants self-reported whether they had experienced any IPV since age 18. We used a three-step bias-adjusted longitudinal latent class analysis to investigate how different patterns of neighborhood deprivation exposure were associated with the odds of experiencing IPV. A total of 32% of women experienced any IPV between ages 18 and 21. Women who consistently lived in deprived neighborhoods (chronic high deprivation) or spent their early childhoods in more deprived neighborhoods and later moved to less deprived neighborhoods (decreasing deprivation) had higher odds of experiencing IPV compared to those who consistently lived in non-deprived neighborhoods. The odds of experiencing IPV did not consistently differ between women who lived in non-deprived neighborhoods during early childhood and later moved to deprived neighborhoods (increasing deprivation) and those stably in non-deprived neighborhoods. Living in more deprived neighborhoods during early childhood, regardless of later exposure, was associated with higher odds of experiencing later IPV. This is congruent with prior research demonstrating the persistent effects of early neighborhood disadvantage on health and well-being. Replication, and underlying mechanisms, should be assessed across contexts.Purpose Even though multiple training methods appear to be effective to improve cardiorespiratory fitness, they also need to be perceived as tolerable or enjoyable by exercisers to maximize long-term behavioral maintenance. Therefore, the purpose of the current study was to compare perceived enjoyment between whole-body interval training (SIT-WB), treadmill-based interval training (SIT-T) and moderate-intensity continuous training (MICT). Method Forty-one healthy adult men (age 23.7 ± 0.7 years, height 1.79 ± 0.01 m, body mass 78.5 ± 1.7 kg; V̇O2max 46.7 ± 7.3 ml.kg-1.min-1) were randomly assigned to SIT-WB, SIT-T, or MICT and underwent 16 weeks of training (3x/w). SIT-WB and SIT-T completed eight 20 s bouts interspersed by 10 s passive recovery, differing as to the exercise mode performed (i.e., calisthenics exercises and treadmill running, respectively) whereas MICT participants ran for 30 min at an intensity below the second ventilatory threshold. Perceived enjoyment was assessed 10 min post-exercise at weeks 1, 5, 9, 13, and 16, using the Physical Activity Enjoyment Scale. Results Compliance was high (~90%) across all three training groups (p = .803). All training modes were rated as enjoyable and no significant within- (F(4, 152) = 1.132, p = .344) or between-group (F(2, 38) = 0.662, p = .521) differences were found during the intervention period. Conclusions These results suggest that SIT-WB can be employed as an enjoyable low-cost alternative to traditional treadmill-based SIT and MICT for up to 16 weeks.Objectives To clear the obscure conclusion on the prediction value of paroxysmal nocturnal haemoglobinuria (PNH) clones in severe aplastic anaemia (SAA) patients treated with immunosuppressive therapy (IST). Methods We retrospectively analyzed 219 consecutive SAA patients treated with IST from October 2008 to October 2015 and evaluated the haematological responses to IST. Results The presence of a PNH clone was detected in 55 (25.1%) patients prior to IST [37/88 by flow cytometry (FCM) and 18/131 by fluorescent aerolysin (FLAER)] and 27 disappeared after IST (23/37 in initial FCM group, 4/18 in initial FLAER group, p = 0.