McMahon Martinez (lotionyam34)

groups was statistically significant (X22=10.5; P=.001). CONCLUSIONS This study was the first contribution to investigating the potential impact of a culturally adapted internet-delivered treatment on depressive symptoms for college students as compared with a WL control group in South America. Future research should focus on identifying variables associated both with premature dropout and treatment withdrawal at follow-up. TRIAL REGISTRATION ClinicalTrials.gov NCT03062215; https//clinicaltrials.gov/ct2/show/NCT03062215. ©Alicia Salamanca-Sanabria, Derek Richards, Ladislav Timulak, Sarah Connell, Monica Mojica Perilla, Yamilena Parra-Villa, Leonidas Castro-Camacho. Originally published in JMIR Mental Health (http//mental.jmir.org), 31.01.2020.BACKGROUND To date, several medication adherence apps have been developed. However, the existing apps have been developed without involving relevant stakeholders and were not subjected to mobile health app guidelines. In addition, the usability and utility of these apps have not been tested with end users. OBJECTIVE This study aimed to describe the usability and utility testing of a newly developed medication adherence app-Med Assist-among ambulatory care patients in Malaysia. METHODS The Med Assist app was developed based on the Theory of Planned Behavior and the Nielson usability model. Beta testing was conducted from March to May 2016 at a primary care clinic in Kuala Lumpur. Ambulatory care patients who scored ≥40% on the electronic health literacy scale, were aged ≥21 years, and were taking two or more long-term medications were recruited. Two rounds of in-depth interviews were conducted with each participant. The first interview, which was conducted upon participant recruitment, was to assess the usabil and uHealth (http//mhealth.jmir.org), 31.01.2020.The extensive feedback from the auditory cortex (AC) to the inferior colliculus (IC) supports critical aspects of auditory behavior but has not been extensively characterized. Previous studies demonstrated that activity in IC is altered by focal electrical stimulation and pharmacological inactivation of AC, but these methods lack the ability to selectively manipulate projection neurons. We measured the effects of selective optogenetic modulation of cortico-collicular feedback projections on IC sound responses in mice. Activation of feedback increased spontaneous activity and decreased stimulus selectivity in IC, whereas suppression had no effect. To further understand how microcircuits in AC may control collicular activity, we optogenetically modulated the activity of different cortical neuronal subtypes, specifically parvalbumin-positive (PV) and somatostatin-positive (SST) inhibitory interneurons. We found that modulating the activity of either type of interneuron did not affect IC sound-evoked activity. Coity only during specific behavior, for example, perhaps when we are listening for a specific sound like the ringing of a phone. Understanding how the brain processes sound is important for understanding how we communicate and why we appreciate music. It could also help in treating hearing loss. Stimulating the inferior colliculus using a device implanted in the brainstem can improve hearing in people with certain types of deafness. Strengthening or weakening the feedback pathway from the auditory cortex to the inferior colliculus could make these implants more effective. In the future, it may even be possible that stimulating the pathway directly could restore hearing without any implant being required. © 2020, Blackwell et al.Carotenoids are a core plastid component and yet their regulatory function during plastid biogenesis remains enigmatic. A unique carotenoid biosynthesis mutant, carotenoid chloroplast regulation 2 (ccr2), that has no prolamellar body (PLB) and normal PROTOCHLOROPHYLLIDE OXIDOREDUCTASE (POR) levels, was used to demonstrate a regulatory function for carotenoids and their derivatives under varied dark-light re