Karstensen Yates (lioncoil81)

P  less then  0.01). CONCLUSIONS The combination of methazolamide and theophylline in the prescribed dosages is not recommended for use at high altitude as it appears to have no measurable effect on AMS and can impair aerobic performance. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Intentional weight loss can increase health risk in the long-term, despite short-term benefits, because human adipose tissue is widely contaminated with various lipophilic environmental contaminants, especially persistent organic pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new risk factor for common metabolic diseases and cardiovascular diseases. The amount of POPs released from adipocytes to the circulation increases during weight loss, thereby increasing POPs exposure of other critical organs. Possible harmful effects due to release of POPs during weight loss are opposite to those usually expected from losing weight. It is speculated that this tradeoff can explain recent puzzling findings on intensive weight loss. The presence of POPs in adipose tissue adds a challenge to weight management and an optimal strategy of weight management needs to consider both fat mass and dynamics of POPs. © 2020 WILEY Periodicals, Inc.BACKGROUND Engaging in meaningful activity is an important contributor to well-being in late life. This study aimed to develop a new measure of meaningful and enjoyable activities in people living with mild dementia. METHODS The study consisted of four phases 1) a review of measures of meaningful activity in older people; 2) interviews with people with dementia and their carers (n = 32), 3) expert opinion; and 4) feasibility testing in a pilot randomised controlled trial (n = 63). RESULTS The development process resulted in a 20-item questionnaire. The Meaningful and Enjoyable Activities Scale (MEAS) evidenced appropriate levels of internal consistency (α = 0.79). Higher scores correlated with higher functional independence (r = -.605, P less then .001), patient (r = .330, P = .010) and carer-rated patient quality of life (r = .505, P less then .001). Multiple regression analyses showed that functional independence made a significant independent contribution in predicting higher levels of meaningful activity (F[7,45] = 6.75, P less then .001, R2 = .512; β = -.444, P = .001). Confirmatory factor analysis indicated that a revised three-factor 9-item model provided good fit for the data (X2  = 22.74, P = 0.54, GFI = 0.93, RMSE = 0.00), with leisure-time physical activity, social engagement and mentally stimulating activities as the key dimensions. CONCLUSION Our study provides support for the construct of meaningful activity in people with mild dementia. selleck kinase inhibitor Although we find preliminary evidence that the MEAS has adequate psychometric properties, future large scale studies are required to test its validity further and responsiveness to change. This article is protected by copyright. All rights reserved.AIMS This systematic review aimed to identify school-based interventions for ensuring mental health and well-being of adolescents, synthesize existing interventions and summarize the quality of identified studies. DESIGN A systematic review, analysis and synthesis were performed. DATA SOURCES Search was performed in Cochrane Library, PsychARTICLES, Web of Science, CINAHL and Medline. REVIEW METHODS Literature search was performed in March 2019 using inclusion and exclusion criteria. PRISMA guidelines were followed. Identified records were reviewed by title, abstract and by the full text by two independent researchers. Three authors independently made a quality assessment of the included studies. Included studies were extracted and synthesized. A s