Crawford Brandt (knotcloudy9)

Collectively, these methods are termed armored CAR T-cell therapy, and in this review, we will discuss the range of armored CAR T-cell approaches which have been investigated to date. To evaluate various selected Pentacam HR indices in a cohort of soft contact lens (SCL) wearers before and after SCL discontinuation. Ninety right eyes of 90 SCL wearers (group 1) were compared to healthy controls (group 2). For group 1 eyes, Pentacam HR images were captured within one hour of SCL removal and after one month of discontinuation. The evaluated indices included curvature, elevation, and pachymetric parameters. Elevation indices and two pachymetric indices (central corneal thickness and thinnest corneal thickness) did not show significant differences, either between the two groups or in group 1 after SCL discontinuation. Some pachymetric indices (average and maximum corneal pachymetry progression indices, and maximum Ambrosio's relational thickness index) showed statistically significant (P-value <0.001), yet clinically irrelevant differences. Contrarily, changes in curvature indices were both statistically significant (P-value <0.001) and clinically relevant. From a clinical point of view, many elevation and pachymetric indices are robust against SCL wear, and can be relied upon for corneal ectasia screening of SCL wearers, even without abstaining from wearing SCLs. From a clinical point of view, many elevation and pachymetric indices are robust against SCL wear, and can be relied upon for corneal ectasia screening of SCL wearers, even without abstaining from wearing SCLs. To identify the etiologies, clinical course and management of acute acquired comitant esotropia in Ramathibodi Hospital, Thailand. Thirty patients who were diagnosed with acute acquired comitant esotropia at Ramathibodi Hospital from January 1 2017 to December 31 2019 were identified using electronic medical records, from which demographic, etiology, clinical course and management, laboratory, and neuroimaging data were collected. The etiologies of acute acquired comitant esotropia were Swan (16.67%), Burian-Franceschetti (30.00%), Bielschowsky (36.67%), Arnold Chiari malformation (3.33%) and decompensated esophoria (13.33%). Mean age of onset was 19.8 ± 18.3 years. Mean angle of esodeviation was 28.4 ± 12.1 prism diopters for distance fixation and 29.3 ± 11.8 prism diopters for near fixation. Refraction differed between age groups children under 10 years had mild hyperopia (median +0.63 diopters, first quartile +0.25 diopters, third quartile +0.75 diopters) and teenagers (10-18 years old) had emmetropiinocular function in our patients. Bielschowsky was the most common etiology of acute acquired comitant esotropia in our study. We suggest that refraction should be performed in all patients with acute acquired comitant esotropia. Most etiologies were benign and might not require neuroimaging. However, neuroimaging is recommended in those with atypical presentations, such as nystagmus, headache, or cerebellar signs. Surgical intervention with a 0.5-1.0 mm increase in recession was effective for restoring ocular alignment and binocular function in our patients. To compare the 12-month efficacy of intravitreous aflibercept (IVA) injection between eyes with pachychoroid neovasculopathy and neovascular age-related macular degeneration (AMD). Retrospective, comparative case series analysis. Twenty-seven eyes with pachychoroid neovasculopathy and sixty-three eyes with neovascular AMD. All patients received three initial monthly, followed by bimonthly, IVA injections. Twelve months after initial treatment, the mean best-corrected visual acuity (BCVA) had improved both in pachychoroid neovasculopathy (from 0.28 to 0.14 logMAR; = 0.001) and neovascular AMD (from 0.40 to 0.29 logMAR; < 0.001). Twelve months after initial treatment, eyes with