Raynor McGuire (juneinch52)
Atrial fibrillation was more common in the tosedostat arm as well. The results of the present study show that the addition of tosedostat to standard chemotherapy does negatively affect the therapeutic outcome of elderly AML patients.This study aimed first to develop an experimental model of obesity and metabolic syndrome over 14 weeks using a diet called "cafeteria", which is a high-fat diet, to evaluate its consequences on the biochemical and morphometric parameters in ITELV2006 strain rabbits. Second, the trial aimed to evaluate the effect of two strains of probiotics, these being Bifidobacterium animalis subsp. lactis BB-12® and Lactobacillus plantarum 299v®, on the obesity and MetS induced during the first experiment. Overall, the results of the "cafeteria" diet demonstrated significant changes in numerous biochemical and morphometric parameters, reproducing obesity and the main clinical manifestations of the metabolic syndrome in humans. The administration of the two probiotic strains demonstrated an impact on certain parameters of obesity and induced MetS. This study makes it possible to conclude that probiotics could be useful in the treatment of obesity and metabolic syndrome of rabbits, but in a dependent manner. Furthermore, this study evidenced the importance of selecting specific probiotic strains and dosages to achieve desirable results on rabbits or other species.Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped in a self-assembled oil-in-water (O/W) emulsion system by using CaCO3 as the stabilizer. The emulsion droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected by varying the processing (homogenization speed and time) and formulation (CaCO3 and TRF concentrations) parameters. Our findings indicated that the combination of 5000 rpm homogenization speed, 15 min homogenization time, 0.75% CaCO3 concentration and 2% TRF concentration resulted in a high EE of tocotrienols (92.59-99.16%) and small droplet size (18.83 ± 1.36 µm). The resulting emulsion system readily released the entrapped tocotrienols across the pH range tested (pH 1-9); with relatively the highest release observed at pH 3. The current study presents a potential pH-sensitive emulsion system for the entrapment and delivery of palm tocotrienols.The objective of the study was to obtain a new biodegradable graft polymer by performing two chemical processes first, a transesterification reaction between carboxylic acid's salt and ethyl acrylate's ester, followed by polymerization of the vinyl group from the ethyl acrylate monomer via free radicals. The copolymer's FTIR shows an absence of ethyl bands, while the characteristic band of pyranose is maintained, which confirms the monomer's graft. TGA analysis shows that sodium alginate had three decomposition temperatures 103 °C due to dehydration, 212 °C associated with the destruction of glycosidic bonds, and 426 °C due to conversion of alginate into Na2CO3. The copolymer presents four processes at different temperatures, i.e., evaporation of alcohol at 65 °C, decomposition of ungrafted alginate at 220 °C, copolymer decomposition at 298 °C, and degradation of fragments into carbonate at 423 °C. The evaluation of the action of fungal growth on the copolymer was higher than 50%, which means it is an excellent material to be biodegraded.The global burden of chronic kidney disease (CKD) intertwined with cardiovascular disease has become a major health problem. Oxidative stress (OS) plays an important role in the pathophysiology of CKD. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) antioxidant system plays a critical role in kidney protection by regulating antioxidants during OS. Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a
