Pickett Dyer (jumbofact35)

Introduction Factor XI (FXI) deficiency is associated with highly variable bleeding, including excessive gynecologic and obstetrical bleeding. Since approximately 20% of FXI-deficient women will experience pregnancy-related bleeding, careful planning and knowledge of appropriate hemostatic management is pivotal for their care. Areas covered In this manuscript, authors present our current understanding of the role of FXI in hemostasis, the nature of the bleeding phenotype caused by its deficiency, and the impact of deficiency on obstetrical care. The authors searched PubMed with the terms, "factor XI", "factor XI deficiency", "women", "pregnancy" and "obstetrics" to identify literature on these topics. Expectations of pregnancy related complications in women with FXI deficiency, including antepartum, abortion-related, and postpartum bleeding, as well as bleeding associated with regional anesthesia are discussed. Recommendations for the care of these women are considered, including guidance for management of prophylactic care and acute bleeding. Expert commentary FXI deficiency results in a bleeding diathesis in some, but not all, patients, making treatment decisions and clinical management challenging. Currently available laboratory assays are not particularly useful for distinguishing patients with FXI deficiency who are prone to bleeding from those who are not. There is a need for alternative testing strategies to address this limitation.The transition from face-to-face teaching to online platform delivery for many institutions has presented positive examples of medical educators' problem-solving abilities. However, this has led to many online sessions following identical formats, providing highly similar learning experiences for students' week-after-week with less variety than from face-to-face deliveries. Selleckchem 2-Aminoethyl The use of serious games, which are games primarily focussed on education, to teach medical and health sciences has previously shown benefit1 and can be incorporated to break the monotony of online lectures and repetitive content delivery.Due to the COVID-19 pandemic, North Bristol NHS Trust (NBT) doctors were redeployed to unfamiliar clinical teams, where they would work at the level of a fully-registered Foundation doctor. As undergraduate clinical teaching fellows, we were re-purposed to rapidly produce a training programme to refresh the medical knowledge of doctors who were from a wide variety of non-medical specialities and grades. Building on our experience of facilitating medical students, wedevised medical ward-based scenarios in an informal Objective Structure Clinical Examination (OSCE) style to promote focused active learning and prompt further independent study.Selecting appropriate cancer models is a key prerequisite for maximizing translational potential and clinical relevance of in vitro oncology studies. We developed CELLector an R package and R Shiny application allowing researchers to select the most relevant cancer cell lines in a patient-genomic-guided fashion. CELLector leverages tumor genomics to identify recurrent subtypes with associated genomic signatures. It then evaluates these signatures in cancer cell lines to prioritize their selection. This enables users to choose appropriate in vitro models for inclusion or exclusion in retrospective analyses and future studies. Moreover, this allows bridging outcomes from cancer cell line screens to precisely defined sub-cohorts of primary tumors. Here, we demonstrate the usefulness and applicability of CELLector, showing how it can aid prioritization of in vitro models for future development and unveil patient-derived multivariate prognostic and therapeutic markers. CELLector is freely available at https//ot-cellector.shinyapps.io/CELLector_App/ (code at https//github.com/francescojm/CELLector and https//github.com/francescojm/CELLector_App).Complex networks of regulatory relationships between protein kinases comprise a major