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Esophageal neuroendocrine carcinoma (ENEC) is an extremely rare type of tumor characterized by a high malignant potential, rapid growth, and poor prognosis. Because the standard therapy for ENEC has been poorly defined, we herein aimed to attain a clear view of the current state of treatment for ENEC by performing a large-scale, multicenter study. We conducted a questionnaire-based, retrospective clinical review of 142 patients with ENEC treated at 37 hospitals accredited by the Japan Esophageal Society from January 2010 to December 2015. The most frequent main treatment performed was an operation, followed by chemoradiotherapy, chemotherapy, and endoscopic submucosal dissection. Selleckchem Rolipram Among the 67 patients who underwent surgery, 28 (19.7%) were not accurately diagnosed with NEC or a combined NEC tumor by pretreatment biopsy. The 5-year overall survival rate of all patients was 33.2%. Among patients with Stages III and IV disease, the prognosis was significantly better in patients who underwent chemoradiotherENEC.It is assumed that the difference between voluntary and involuntary autobiographical memories lies in the intentionality to retrieve a memory assigned by the experimenter. Memories that are retrieved when people are instructed to do so in response to cues are considered voluntary (VAMs), those that pop up spontaneously are considered involuntary (IAMs). VAMs and IAMs so classified are also found to differ in terms of phenomenological characteristics, such as perceived accessibility, vividness etc. These differences are assumed to be due to differences in intentionality and the different retrieval processes at play. It is possible, however, that these differences (which are subjective attributions of phenomenological characteristics) are the result of metacognitive beliefs of what IAMs and VAMs should be. In two experiments, we investigated the possible role of these metacognitive beliefs. Participants rated IAMs and VAMs on a number of phenomenological characteristics in two conditions, when these memories were presented in blocks that specified whether they were retrieved in a voluntary or involuntary task, or when presented in a mixed list with no information provided. If metacognitive beliefs influence the reporting of memory properties, then the block presentation would increase the differences between the characteristics of the two types of memories. The results showed that, besides replicating the characteristics of IAMs and VAMs already observed in the literature, there were almost no differences between the blocked and the mixed lists. We discuss the results as supporting the idea that the difference in characteristics attributed to IAMs and VAMs reflect a genuine difference in the nature of the retrieval and is not the result of pre-existing metacognitive belief on what a voluntary and an involuntary memory should be.Patients with chronic thromboembolic pulmonary hypertension (CTEPH) need anticoagulant therapy for life. Conventionally, vitamin K antagonists (VKAs) have been used and data about direct oral anticoagulants (DOACs) in CTEPH patients are lacking. Recently, balloon pulmonary angioplasty (BPA) has emerged as a treatment option for CTEPH. However, there are no reports examining the effects of DOACs and VKAs on the hemodynamics of patients after BPA. The aim of this study was to compare DOACs and VKAs regarding the hemodynamic changes in patients with CTEPH treated by BPA. Patients who were treated by BPA and underwent follow-up right heart catheterization 6 ± 1 months after the final BPA procedure were included in this study. The subjects were divided into two groups based on the anticoagulant administered, and hemodynamic changes (mean pulmonary artery pressure, mPAP; pulmonary vascular resistance, PVR; cardiac index, CI) were assessed. Of the 65 consecutive patients, 29 met the inclusion criteria (DOAC-group n = 14, VKA-group n = 15). Compared to pre-BPA,