Esbensen Rasch (handleturn8)
Выявлена связь между отсутствием и/или снижением экспрессии белков MSI (преимущественно PMS2 и MLH1, в меньшей степени MSH6) и степенью дифференцировки РМП, а также стадией T, обнаружена тенденция к снижению экспрессии исследуемых белков в зоне инвазивного роста опухоли, что подтверждает прогностическую роль белков MSI. Наиболее выраженную гетерогенность ИГХ-экспрессии отметили для MSH6, наименьшую - для PMS2. Среди опухолей с гетерогенным окрашиванием преобладали низкодифференцированные поверхностные карциномы (T1). В случае позитивного PD-L1-статуса отмечены снижение экспрессии PMS2 и MLH1 и выраженная экспрессия MSH6, достоверной связи не выявлено из-за малого числа этих случаев. Авторы считают необходимым проведение дальнейших исследований связи MSI-фенотипа и PD-L1-статуса РМП.BACKGROUND The aim of this study was to evaluate the feasibility and safety of intermittent splenic artery occlusion plus gauze compression in treating iatrogenic splenic injury. MATERIAL AND METHODS We retrospectively analyzed 12 iatrogenic splenic injury cases (grade I to III) treated with intermittent splenic artery occlusion plus gauze compression. learn more The hemostatic effect was then observed after unblocking and decompression. The total operation time, gauze compression time, total blood loss, blood loss from the injured spleen, and platelet counts of each patient before and 1 week after surgery were noted. RESULTS The average operation time was 209.58±57.11 min, and the average gauze compression time after spleen artery occlusion was 23.75±4.33 min. The average total blood loss and blood loss due to iatrogenic spleen injury were 468.33±138.22 ml and 264.17±165.72 ml, respectively. Two cases (both grade I) had successful hemostasis after 15 min of splenic artery occlusion and wound compression. Another 9 cases (all grade II) and 1 case (grade III) attained hemostasis after 25 min and 30 min, respectively, of splenic artery occlusion and wound compression. The platelet counts of all patients were within the normal range before and 1 week after surgery. No postoperative complications occurred. CONCLUSIONS Intermittent splenic artery occlusion plus gauze compression is a simple and effective treatment for iatrogenic splenic injury.Cobalt nanoparticles with diameters of 8 nm have recently shown promising performance for biomedical applications. However, it is still unclear how the shape of cobalt clusters changes with size when reaching the nanoparticle range. In the present work, density functional theory calculations have been employed to compare the stabilities of two non-crystalline (icosahedron and decahedron) shapes, and three crystalline motifs (hcp, fcc, and bcc) for magic numbered cobalt clusters with up to 1500 atoms, based on the changes in the cohesive energies, coordination numbers, and nearest-neighbour distances arising from varying geometries. Obtained trends were extrapolated to a 104 size range, and an icosahedral shape was predicted for clusters up to 5500 atoms. Larger sized clusters adopt hcp stacking, in correspondence with the bulk phase. To explain the crystalline/non-crystalline crossovers, the contributions of the elastic strain density and twin boundary from the specimen surfaces to the cohesive energy of different motifs were evaluated. These results are expected to aid the design and synthesis of cobalt nanoparticles for applications ranging from catalysis to biomedical treatments.TiO2-NiO composite nanorods were synthesized by combining hydrothermal growth of TiO2 nanorods and sputtering deposition of NiO film. Crystalline NiO coverage films with various thicknesses were sputter coated onto TiO2 nanorods by controlling NiO sputtering duration. The crystallographic analyses demonstrate that crystalline rutile TiO2-cubic NiO composite nanorods were formed herein. In comparison with pristine TiO2 and NiO, the coverage of NiO crystals on the TiO2 nanorods led to an enhanced photodegradation activity of the TiO2-N
