Aarup Lykke (hailporch63)

17). Results demonstrate that VLAS and RadLAE were superior indicators of EchoLAE compared to VHS in dogs with known or suspected CVDz. Both VLAS and VHS are useful predictors of EchoB2 in dogs with subclinical MMVD. When echocardiography is unavailable, VLAS represents a useful radiographic measurement to aid clinical management of dogs with known or suspected CVDz.Proton-responsive photochromic molecules are attractive for their ability to react on non-invasive rapid optical stimuli and the importance of protonation/deprotonation processes in various fields. Conventionally, their acidic/basic sites are on hetero-atoms, which are orthogonal to the photo-active π-center. Here, we incorporate azulene, an acid-sensitive pure hydrocarbon, into the skeleton of a diarylethene-type photoswitch. The latter exhibits a novel proton-gated negative photochromic ring-closure and its optical response upon protonation in both open and closed forms is much more pronounced than those of diarylethene photoswitches with hetero-atom based acidic/basic moieties. The unique behavior of the new photoswitch can be attributed to direct protonation on its π-system, supported by 1H NMR and theoretical calculations. Our results demonstrate the great potential of integrating non-alternant hydrocarbons into photochromic systems for the development of multi-responsive molecular switches.Despite much intense investigation on the C2 H2 /CO2 separation, the trade-off between the adsorption capacity and separation selectivity is still tricky. To overcome the dilemma, we have rationally synthesized an ultra-stable fluorinated hybrid porous material SIFSIX-Cu-TPA with the ith-d topology. Completely differing from the famous pillar-layer fluorinated materials, SIFSIX-Cu-TPA possesses a unique pillar-cage structure, in which the SiF6 2- anions cross-link two adjacent metal nodes as pillars to stabilize the three-dimensional framework constructed by icosahedral and tetrahedral cages. As anticipated, SIFSIX-Cu-TPA has high BET surface area (1330 m2 g-1 ) as well as high C2 H2 uptake (185 cm3 g-1 at 298 K and 1 bar). At the same time, due to the obvious difference in the adsorption performance of CO2 and C2 H2 especially in the low pressure area, SIFSIX-Cu-TPA also exhibits an excellent C2 H2 /CO2 separation performance (breakthrough time up to 68 min g-1 at 298 K and 1 bar).Polyene cyclizations are capable of producing molecular complexity in a single step. While classical systems are limited to simple alkyl substitution patterns only, bifunctional polyenes take advantage of the unique reactivity of higher-functionalized alkenes. Here, we highlight the potential of these variants for the synthesis of structurally complex polycycles involving unprecedented termination steps. We also want to provide a stimulus for the development of novel modes of cyclization that involve bifunctional units to enable efficient synthesis of yet inaccessible natural products.We investigated synaptic mechanisms in the hippocampus that could explain how loss of circadian timing leads to impairments in spatial and recognition memory. Experiments were performed in hippocampal slices from Siberian hamsters (Phodopus sungorus) because, unlike mice and rats, their circadian rhythms are easily eliminated without modifications to their genome and without surgical manipulations, thereby leaving neuronal circuits intact. Recordings of excitatory postsynaptic field potentials and population spikes in area CA1 and dentate gyrus granule cells revealed no effect of circadian arrhythmia on basic functions of synaptic circuitry, including long-term potentiation. However, dentate granule cells from circadian-arrhythmic animals maintained a more depolarized resting membrane potential than cells from circadian-intact animals; a significantly greater proportion of these cells depolarized in response to the cholinergic agonist carbachol (10 μM), and did so by increasing their membrane potential three-fol