Mortensen Zachariassen (greasetenor65)
CONCLUSION The in-silico activity of small molecules (enzymes, proteins, among others) might be used as pharmacological tools to develop candidate compounds for the treatment of leishmaniasis. As some pharmacologically active compounds may act on more than one target, additional studies of the mechanism (s) of action of potent antileishmanial compounds might help to better understand their pharmacological action. Also, the optimization of the promising antileishmanial compounds might improve their biological activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIM AND OBJECTIVE Herein, a novel heterogeneous catalytic system constructed of iron oxide and palladium nanoparticles is presented. Firstly, a convenient synthetic pathway for preparation of this catalytic system is introduced, then the application of the fabricated nanocomposite in the Pd-catalyzed C─C coupling reactions is monitored. High reaction yields (98%) have been obtained in a short reaction time, through applying this catalytic system. MATERIALS AND METHODS Fe3O4/P4VP-Pd catalytic system was fabricated via an in situ method by 4-vinylpyridine (4-VP). In this regard, all the essential structural analyses such as FT-IR, EDX, VSM, and TGA have been performed on the Fe3O4/P4VP-Pd catalytic system to investigate its properties. The spherical morphology of the NPs and their uniform size have also been studied by SEM method. selleckchem Further, the reaction progress was controlled by thin-layer chromatography. Finally, NMR analysis was used to identify the synthesized biphenyl pharmaceutical derivatives. RESULTS High efficiency of this catalytic system has been precisely investigated and the optimal conditions was determined. The catalytic process is carried out in 20 min, under mild conditions (room temperature). Then, the purification process is easily performed via magnetic separation of the catalyst NPs. After completion of the synthesis reaction, the NPs were collected, washed, and reused for several times. CONCLUSION Among recently reported heterogeneous catalytic systems, Fe3O4/P4VP-Pd is recommended due to its high catalytic performance, convenience of the preparation process, excellent biocompatibility, economic benefits, and well reusability. Overall, in order to save time in the complex synthetic processes and also prevent using so much chemical reagents and solvents for the purification process, the presented catalytic system could be suitable for scalling up and applying for the industrial applications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Parkinson's disease is one of the most severe progressive neurodegenerative diseases which have a mortifying effect on the health of almost hundreds of millions of people around the globe. The neural cells producing dopamine in the substantia nigra of the brain die out which leads to symptoms like hypokinesia, rigidity, bradykinesia and rest tremor.Parkinsonism cannot be cured but the symptoms can be reduced with the intervention of medicinal drugs, surgical treatments and physical therapies. Delivering drugs to the brain for treating Parkinson's disease is very challenging, the blood brain barrier act as a highly selective semi permeable barrier which refrains the drug from reaching the brain. Conventional drug delivery systems used for Parkinson's disease does not easily cross the blood barrier and further leads to a number of side effects. Recent advancements in drug delivery technologies have facilitated the drug delivery to the brain without flooding the blood stream and by directly targeting the neurons.In the era of Nanotherapeutics, liposomes can be an efficient drug delivery option for brain targeting.Liposomes can facilitate the passage of drugs across the blood brain barrier, enhances the efficacy of the drugs and minimises the side effects related to it. The review aims at providing a broad u
