Honore Dowling (goldtoy9)

We showed that modification of the first two N-terminal residues of the chemokine (K1R or P2G) does not alter the ability of CXCL12 to activate ACKR3. Our results also identified the K1R variant as a G protein-biased agonist of CXCR4. Comparative molecular dynamics simulations of the complexes formed by ACKR3 either with CXCL12 or with the P2G variant identified interactions between the N-terminal 2-4 residues of CXCL12 and a pocket formed by receptor's TM helices 2, 6, and 7 as critical determinants for ACKR3 activation. ©2020 Society for Leukocyte Biology.AIMS To determine the prevalence of potentially inappropriate medication (PIM) use at hospital admission and discharge, and the contribution to hospital admission among residential aged care facility (RACF) residents with and without dementia. METHODS We conducted a secondary analysis using data from a multi-hospital prospective cohort study involving consecutively admitted older adults, aged 75 years or older, who were taking five or more medications prior to hospital admission and discharged to a RACF in South Australia. PIM use was identified using the 2015 Screening Tool for Older Persons' Prescription (STOPP) and 2019 Beers Criteria. An expert panel of clinicians with geriatric medicine expertise evaluated the contribution of PIM to hospital admission. RESULTS In total, 181 participants were included, the median age was 87.5 years and 54.7% were female. Ninety-one (50.3%) had a diagnosis of dementia. Participants with dementia had less PIMs, according to at least one of the two screening criteria, than those without dementia, at admission (dementia 76 (83.5%) vs no dementia 84 (93.3%), p=0.04) and discharge (78 (85.7%) vs 83(92.2%), p=0.16). PIM use was causal or contributory to the admission in 28.1% of study participants (n=45) who were taking at least one PIM at admission. CONCLUSIONS Over 80% of acutely admitted older adults took PIMs at hospital admission and discharge and for over a quarter of these people the admissions were attributable to PIM use. Hospitalisation presents an opportunity for comprehensive medication reviews, and targeted interventions that enhance such a process could reduce PIM use and related harm. This article is protected by copyright. All rights reserved.There are vast numbers of bats, in terms of both individuals and species, in Indonesia, although the precise species count is currently unknown. These bats demonstrate great variation in feeding patterns, with some being insectivorous, frugivorous, nectar-eating or carnivorous. One of the insectivorous bats found on Java Island, Indonesia, is the Javan pipistrelle (Pipistrellus javanicus). This paper presents a detailed morphological description of the tongue and lingual papillae of P. javanicus, using scanning electron microscopy (SEM) and light microscopy (LM). Macroscopically, the elongated tongue of P. javanicus can be divided into three sections the apex, corpus and radix. On the dorsal part of the tongue (corpus), there is a prominence called the mediodorsal lobe, the lobe begin from the end of apex. On the radix, in the medial part, we describe the presence of a sulcus medianus. The SEM and LM observations show that the apex of the tongue bears three types of papillae crown filiform, pronged filiform and fungiform. The corpus bears conical and fungiform papillae, whereas the radix bears vallate, large filiform, small filiform and fungiform papillae. Taken together, these results contribute to research on the tongue anatomy and feeding habits of the bat. © 2020 Blackwell Verlag GmbH.Caregiver responsiveness and presence of secondary attachments play a crucial role in children's socio-cognitive and emotional development, but little is known of their effect on the development of non-human primates. Here we present the results of a 16-month behavioral study conducted on 22 wild infant olive baboons (Papio anubis) at the U