Huffman Cummings (gliderdecade5)

Triage of patients with emergent large vessel occlusion stroke to primary stroke centers followed by transfer to comprehensive stroke centers leads to increased time to endovascular therapy. A Mobile Interventional Stroke Team (MIST) provides an alternative model by transferring a MIST to a Thrombectomy Capable Stroke Center (TSC) to perform endovascular therapy. Our aim is to determine whether the MIST model is more time-efficient and leads to improved clinical outcomes compared with standard drip-and-ship (DS) and mothership models. This is a prospective observational cohort study with 3-month follow-up between June 2016 and December 2018 at a multicenter health system, consisting of one comprehensive stroke center, 4 TSCs, and several primary stroke centers. A total of 228 of 373 patients received endovascular therapy via 1 of 4 models mothership with patient presentation to a comprehensive stroke center, DS with patient transfer from primary stroke center or TSC to comprehensive stroke center, MIST wid a trend towards improved long-term outcomes. Registration URL https//. Endoxifen mw Unique identifier NCT03048292. MIST led to significantly faster initial door-to-recanalization times compared with DS, which was comparable to mothership. This decrease in time has translated into improved short-term outcomes and a trend towards improved long-term outcomes. Registration URL https//. Unique identifier NCT03048292.La-related proteins 7 (LARP7) are a class of RNA chaperones that bind the 3' ends of RNA and are constitutively associated with their specific target RNAs. In metazoa, Larp7 binds to the long non-coding 7SK RNA as a core component of the 7SK RNP, a major regulator of eukaryotic transcription. In the ciliate Tetrahymena the LARP7 protein p65 is a component of telomerase, an essential ribonucleoprotein complex that maintains the telomeric DNA at eukaryotic chromosome ends. p65 is important for the ordered assembly of telomerase RNA (TER) with telomerase reverse transcriptase. Unexpectedly, Schizosaccharomyces pombe Pof8 was recently identified as a LARP7 protein and a core component of fission yeast telomerase essential for biogenesis. LARP7 proteins have a conserved N-terminal La motif and RRM1 (La module) and C-terminal RRM2 with specific RNA substrate recognition attributed to RRM2, first structurally characterized in p65 as an atypical RRM named xRRM. Here we present the X-ray crystal structure and NMR studies of S. pombe Pof8 RRM2. Sequence and structure comparison of Pof8 RRM2 to p65 and human Larp7 xRRMs reveals conserved features for RNA binding with the main variability in the length of the non-canonical helix α3. This study shows that Pof8 has conserved xRRM features, providing insight into TER recognition and the defining characteristics of the xRRM.The agricultural industry has been identified as one of the most hazardous industries in developed countries. The main purpose of this paper was to conduct a comprehensive analysis of agricultural accidents (or injuries) in Taiwan during the period of 2009 to 2018. The occupational accident rates (per 1,000 farmers employed) in Taiwan's agricultural industry showed a decreasing trend over the past decade from 1,486 in 2009 to 1,053 in 2018. This trend could be attributed to the joint-cooperation efforts of the industrial, official, academic, and non-profit parties under the Occupational Safety and Health Act (OSHA) revised in 2013. Although the occupational accident, disability, and other injury rates in all non-agriculture industries were higher than those in the agricultural industry during this period, the fatality rates in the agricultural industry were higher than those in all industries. Finally, some inter-ministerial measures on occupational safety and health issues in the agricultural industry for preventing agricultural accidents or injuries were recommended in the paper. The increase