Clay Hamilton (farmsupply9)

PURPOSE To evaluate posterior capsule opacification (PCO) with a new hydrophobic acrylic intraocular lens (IOL) featuring a new micropatterned membrane, in comparison with a commercially available 1-piece hydrophobic acrylic IOL. SETTING John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. STUDY DESIGN Experimental study. METHODS Twelve New Zealand rabbits had bilateral phacoemulsification and implantation of a ClearSight unpatterned IOL (Group 1), a ClearSight Sharklet-patterned IOL (Group 2), or a control, commercially available IOL (Group 3) (8 IOLs in each group). Slit-lamp examination was performed weekly for 4 weeks. The rabbits were then killed humanely, and their globes enucleated. Capsular bag opacification was assessed from the Miyake-Apple view, and the eyes underwent histopathology. RESULTS The mean postmortem central PCO was 1.87 ± 1.35 in Group 1, 1.06 ± 1.23 in Group 2, and 3.14 ± 0.89 in Group 3. Peripheral PCO was 2.18 ± 1.36 in Group 1, 1.5 ± 1.03 in Group 2, and 3.57 ± 0.53 in Group 3. When comparing central and peripheral PCO between Groups 1 and 3, the difference was not statistically significant, but it was statistically significant between Groups 2 and 3 (P = .003 and P = .0003, t test with Bonferroni correction). CONCLUSIONS Unique discontinuous features comprising the micropattern allow for focal adhesions to be precisely guided and therefore controlling cell migration. The patterned membrane incorporated on the posterior surface of the IOL significantly reduced capsular bag opacification compared with a commercially available control IOL.PURPOSE To determine the most accurate method of estimating scleral-spur-to-scleral-spur (STS) distance for ophthalmologists without access to an anterior chamber optical coherence tomography (AS-OCT) instrument when selecting an anterior chamber intraocular lens (AC IOL). SETTING Robert Cizik Eye Clinic, Houston, TX. DESIGN Prospective cohort study. METHODS The eyes of 65 participants aged 18 years or older were imaged by the Lenstar LS 900 optical biometer and CASIA SS-1000 swept-source Fourier-domain AS-OCT. Eyes were excluded if the anterior segment anatomy was significantly altered and the angle could not be visualized. When both eyes were eligible, 1 eye was randomly selected. The white-to-white (WTW) distance, STS distance, and axial length were recorded and compared. The difference between STS and horizontal WTW was calculated for each meridian. The mean (±SD) differences, 95% limits of agreement, and Bland-Altman agreement were computed for each pair of STS and WTW measurements. RESULTS The study comprised 65 eyes of 65 participants. In nearly every case, WTW + 0.5 and WTW + 1 overestimated STS. The horizontal WTW without adjustment was the best predictor of STS. The WTW best corresponded to the vertical STS meridian (6 to 12 o'clock) and not the horizontal meridian (3 to 9 o'clock), along which AC IOLs are traditionally placed. CONCLUSIONS The horizontal WTW method without an adjustment factor most accurately estimated STS distance and should be used to select AC IOL size when AS-OCT is not available. If AS-OCT is available, it should be used instead. In addition, AC IOLs should be placed in a vertical orientation rather than the traditional horizontal orientation to minimize sizing errors.PURPOSE To assess the repeatability and reproducibility of dynamic corneal response (DCR) parameters obtained by ultra-high-speed Scheimpflug imaging (Corvis ST); in keratoconic patients. SETTING Clinics in Germany, Italy, and Brazil. DESIGN Prospective, observational study. selleck chemicals llc METHODS Patients were examined 3 times using 2 different dynamic Scheimpflug analyzers (Corvis ST) to obtain repeatability and reproducibility. The reliability of intraocular pressure (IOP), biomechanically corrected IOP (bIOP), pachymetry, and DCR parameters were assessed by the coefficient of repeatability, coefficient of variation (CoV), intraclass corre