Norup Hinrichsen (epoxymanx63)

Purpose To explore the therapeutic effects and prognosis of osimertinib combined with docetaxel for non-small cell lung cancer (NSCLC). Methods A total of 94 patients with NSCLC diagnosed in the oncology department of our hospital were selected and randomly divided into two groups of 47 patients each. Patients in the control group took osimertinib tablets, while patients in the drug combination group were given intravenous docetaxel in addition to the oral administration of osimertinib. The therapeutic effects, inflammatory factors, toxic and side effects and factors affecting prognosis were analyzed in the two groups. Results The overall response rate (RR) and disease control rate (DCR) in the drug combination group were 25.53% and 57.44%, respectively, which were higher than those in the control group. Before treatment, there were no obvious differences in terms of the levels of vascular endothelial growth factor (VEGF), matrix metallopeptidase-9 (MMP-9) and cytokeratin19 fragment antigen 21-1 (CYFRA21-1) bng the medication period. Patients with smoking history, advanced TNM stage and high KPS score tend to have a poor prognosis.Purpose Ovarian cancer (OC) is one of the most common malignancies in females with high mortality rate. MicroRNAs (miRNAs or miRs) serve as oncogenes or tumor suppressors in various human cancer types, including OC. The aim of this study was to explore the roles of miR-492 in OC. Methods Two human ovarian cancer cell lines, SKOV3 and CAOV3, and a normal ovarian cell line IOSE80 were used in this study. Real-time quantitative polymerase chain reaction (RT-qPCR) was conducted to measure the mRNA levels of miRNAs and genes. The protein levels of epithelial-mesenchymal transition (EMT) associated genes were calculated using Western blot. Transwell assay was utilized to evaluate the migratory and invasive capacities. Results MiR-492 was overexpressed while SRY-box 7 (SOX7) was lowly expressed in OC tissues and cells. Upregulation of miR-492 or downregulation of SOX7 predicted poor prognosis of OC patients. MiR-492 regulated the expression of SOX7 via directly binding to the 3'-untranslated region (3'-UTR) of SOX7 mRNA in SKOV3 OC cells. The expression of miR-492 had a negative relationship with SOX7 in OC tissues. MiR-492 promoted the migration, invasion and EMT through SOX7 in SKOV3 cells. SOX7 could partially reverse the role of miR-492 on the migratory, invasive and EMT abilities in SKOV3 cells. Conclusions MiR-492 promoted the migratory, invasive and EMT abilities through SOX7 in OC. This suggested that miR-492/SOX7 axis may be an effective candidate therapeutic target for the treatment of OC.Purpose Human papillomavirus (HPV) involvement in cervical carcinogenesis represents a classical template of analyzing viral-mediated carcinogenesis. Our purpose was to investigate the role of abnormal cyclin D1 protein expression in HPV-mediated squamous intraepithelial lesions (SILs). Methods Eighty cases characterized as squamous intraepithelial lesions (SILs) and also borderline cases with molecularly proven HPV infection were examined. Using liquid-based cytology, we constructed 10 slides, each containing 8 cell spots. Immunocytochemistry (ICC) was performed using an anti-Cyclin D1 antibody. Digital image analysis was also implemented for evaluating objectively the protein expression levels on the corresponding stained slides. Results Cyclin D1 protein overexpression (moderate to high staining intensity values) was observed in 8/80 (10%) cell spots, whereas low expression rates were detected in 72/80 (90%) cases. Cyclin D1 overall expression was strongly associated with the HPV type group (HR-HPV) of the examined cases (p=0.001) and borderline with the cervical intraepithelial neoplasia (CIN) categorization (p=0.06). Concerning the influence of marker's protein expression in SIL cytological categorization, no statistical significance was identified (p=0.10). Conclusions Cyclin D1 overexpression is observed