Lunding Childers (cubjudge36)

Crucial arguments in the debate about the use of transcranial electrical stimulation (tES) as an intervention for children with neurodevelopmental disorders include, besides safety and efficacy issues, neuroethical concerns as well. No agreement has been reached yet in the clinical community about the ethical aspects of stimulating, although not invasively, a developing brain. To investigate ethical concerns about the use of tES in childhood and adolescence, we explored the knowledge and opinions of practitioners (psychologists, pediatricians, child psychiatrists, and rehabilitators) working in the field of rehabilitation of neurodevelopmental disorders (N=106). An online survey was designed to collect information about what practitioners in the neurodevelopmental field think about the therapeutic use of tES in terms of ethical concerns, need for facilitating conditions, openness to alternative treatments, and need for usability. Findings showed that a previous knowledge of tES, the presence of facilitating circumstances, and lower ethical concerns were the stronger predictors of clinical professionals' propensity to use tES for children rehabilitation. The present study is the first to explore the attitudes of clinical professionals toward the therapeutic use of tES in developmental populations, which we claim are useful for furthering the communication directed to the clinical community and its involvement in the discussion about tES-related issues.Transcranial random noise stimulation (tRNS), a non-invasive neuromodulatory technique capable of altering cortical activity, has been proposed to improve the signal-to-noise ratio at the neuronal level and the sensitivity of the neurons following an inverted U-function. The aim of this study was to examine the effects of tRNS on vGLUT1 and GAD 65-67 and its safety in terms of pathological changes. For that, juvenile mice were randomly distributed in three different groups "tRNS 1×" receiving tRNS at the density current used in humans (0.3A/m2, 20min), "tRNS 100×" receiving tRNS at two orders of magnitude higher (30.0A/m2, 20min) and "sham" (0.3A/m2, 15s). Nine tRNS sessions during 5 weeks were administered to the prefrontal cortex of awake animals. No detectable tissue macroscopic lesions were observed after tRNS sessions. Post-stimulation immunohistochemical analysis of GAD 65-67 and vGLUT1 immunoreactivity showed reduced GAD 65-67 immunoreactivity levels in the region directly beneath the electrode for tRNS 1× group with no significant effects in the tRNS 100× nor sham group. The observed results suggest an excitatory effect associated with a decrease in GABA levels in absence of major histopathological alterations providing a novel mechanistic explanation for tRNS effects.Stroke is a major problem worldwide that impacts over 100 million adults and children annually. Rehabilitation therapy is the current standard of care to restore functional impairments post-stroke, however its effects are limited and many patients suffer persisting functional impairments and life-long disability. Noninvasive Brain Stimulation (NIBS) has emerged as a potential rehabilitation treatment option in both adults and children with brain injury. In the last decade, Transcranial Magnetic Stimulation (TMS), Transcranial Direct Current Stimulation (tDCS) and Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) have been investigated to improve motor recovery in adults post-stroke. These promising adult findings using NIBS, however, have yet to be widely translated to the area of pediatrics. The limited studies exploring NIBS in children have demonstrated safety, feasibility, and utility of stimulation-augmented rehabilitation. This chapter will describe the mechanism of NIBS therapy (cortical excitability, neuroplasticity) that underlies its use in stroke and motor function and how TMS, tDCS, and taVNS are applied in adult stroke treatment paradigms. We will then discuss the current state of NIBS i