Santos Bain (cowquart12)

In conclusion, our analysis revealed the different and correlated role of translational control with transcriptional regulation in the HFD-induced mouse fatty liver relative to the control, which indicates critical roles of translational control for liver steatosis; thus, adding a new dimension towards a better understanding and improvement of treatment for NAFLD.It is widely assumed that mindfulness training will lead to a range of benefits, from improved attentional capacities to better decision-making. Indeed, many large corporations have begun to provide workplace mindfulness training with the aim of improving group-based decision-making. Yet, there has been little empirical work testing the effects of mindfulness training on complex group-based task performance. In a randomised experimental study (N = 332), we examine the effects of two different durations of mindfulness training on strategic decision-making using the classic NASA survival task, assessing individual and then group performance. We expected that a longer training duration (seven daily sessions) would be associated with better group performance relative to a "one-off" training session. IDF-11774 We did not find such an association groups in the longer training condition made slightly, but not significantly, more errors than groups in the one-off condition. We did not find any differences across training conditions when examining individual performance. Our findings should be interpreted in light of numerous studies demonstrating the benefits of even short durations of mindfulness practice on cognitive performance. We conclude that our lengthier mindfulness training duration did not confer measurable benefits over a one-off training session at either the individual or the group level on a strategic decision-making task.Immune thrombocytopenia (ITP) can be associated with lymphoproliferative diseases (LPD) or solid tumors. A systematic review of published literature was conducted to evaluate response to treatment of ITP secondary to malignancy. Primary outcome was overall response (complete response+response) to first-line treatments [steroids alone or in combination with intravenous immunoglobulins (IVIg)]. Among secondary outcomes, overall response to second-line treatments [splenectomy, rituximab or thrombopoietin receptor agonists (TPO-RA)] and death were evaluated. Of the retrieved 238 text articles, 108 were analyzable, for a total of 154 patients 142 in 105 case reports and 12 in 3 observational studies. Thirty-nine patients had solid tumors, 114 LPD, and 1 both. The median follow up was 19 months (IQR, 9-40). The overall response was 50% (62% in solid tumors, 46% in LPD) after steroids and 47% (67% in solid tumors, 36% in LPD) after steroids+IVIg, which are lower than historical responses observed in primary ITP (≈80%). The overall responses to rituximab (used in LPD only), splenectomy and TPO-RA (70%, 73% and 92%, respectively) were similar to those observed in primary ITP. Seven patients (6%) died due to bleeding events. ITP secondary to malignancy appears to be associated with unsatisfactory response to first-line treatments.Early detection and treatment of endometrial hyperplasia (EH) is mandatory for endometrial cancer prevention. Several bioactive agents of plant origin have been shown to elicit their chemotherapeutic effect against tumors and cancer via induction of mitochondrial permeability transition(mPT) pore opening. This research was therefore aimed at evaluating the potential chemopreventive effect of methyl palmitate (MP), on estradiol benzoate(EB)-induced EH, looking at the mitochondrial-mediated pathway and other possible mechanisms of action. Mitochondria were isolated using differential centrifugation. The mPT pore, mitochondrial ATPase (mATPase) activity, lipid peroxidation and cytochrome c release were determined by standard methods using spectrophotometer. Uterine interleukin 1b, MDA levels and SOD, GSH activities, were determ