Thomasen Sehested (congotin15)

BACKGROUND Tumour grade is traditionally considered in the management of patients with colorectal cancer. However, a large body of literature suggests that a related feature, namely tumour budding, may have a more important clinical impact. The aim of our study is to determine the correlation between tumour grade and tumour budding and their impact on patient outcome. METHODS A retrospective collective of 771 patients with colorectal cancer were included in the study. Clinicopathological information included tumour grade (World Health Organisation 2010; G1, G2 and G3) and tumour budding evaluated as BD1, BD2 and BD3 and representing 0-4 buds, 5-9 buds and 10 or more buds per 0.785 mm2, respectively. RESULTS Tumour grade and tumour budding were correlated (p  less then  0.0001, percent concordance 33.8%). Of the BD1 cases, 18.1% were of G3. Bromelain manufacturer Only two BD3 cases were G1. Both high tumour grade and tumour budding were associated with higher pT, lymph node metastasis, distant metastasis and lymphatic and venous vessel invasion (p  less then  0.01, all), but only tumour grade was additionally associated with right-sided tumour location and mucinous histology. Higher tumour budding led to worse overall (p = 0.0286) and disease-free survival (p = 0.001), but tumour grade did not. Budding was independent of tumour grade in multivariate analysis. DISCUSSION Tumour grade and tumour budding are distinct features, as recognised by their different clinicopathological associations, reflecting different underlying biological processes. Nonetheless, tumour budding seems to outperform tumour grade in terms of predicting disease-free survival. BACKGROUND Outcomes of endovascular treatment of anterior cerebral artery (ACA) aneurysms are still not well-characterized. OBJECTIVE The study aimed to review the clinical effect, procedure-related complications and follow-up outcomes and to evaluate the safety and efficacy of endovascular treatment of ACA aneurysms in our center experience. METHODS From August 2014 to August 2018, a total of 75 consecutive patients with 77 ACA aneurysms were treated via the endovascular approach after providing informed consent. A retrospective review of the clinical, radiological, and endovascular details of these patients was conducted. RESULTS The mortality and the morbidity in this study were 4% and 9.3%, respectively. Compared with A1 and A2 aneurysms, intraoperative rupture was more common in A3 aneurysms (P = 0.029). Difference between the ruptured and unruptured aneurysms in the distribution of therapeutic strategy (P = 0.003) and immediate embolization degree (P = 0.004) was also significant. Statistical analysis demonstrated that the larger aneurysm (P = 0.031) was, the greater the ratio of aneurysm size to parent artery diameter (P = 0.029) was, the more likely the unruptured aneurysms were to occur ischemic events. Higher Hunt-Hess grade (P = 0.0066) was an independent risk factor for poor clinical outcome. CONCLUSION Endovascular treatment is feasible and effective for ACA aneurysms. OBJECTIVE The aim of this study was to investigate the burst suppression (BS) pattern on intra-operative electrocorticography (ECoG) in patients with temporal lobe epilepsy (TLE) and the surgical outcome. PATIENTS AND METHODS From January 2017 to June 2017, 45 patients with TLE underwent temporal lobe resection with intra-operative ECoG at the Beijing Institute of Functional Neurosurgery of Xuanwu Hospital of Capital Medical University, China. The scalp EEG, pre-operative and post-operative ECoG were analyzed. Surgical outcome was evaluated with Engel's classification every 3 months, 6 months and 1 year after surgery. RESULTS Before temporal lobe resection the ECoG showed a variable amount of interictal spiks in all patients. A different pattern of burst suppression (BS) was recorded in 33.3% (n = 15; male7, female8; mean age, 26.9 years; range 3-45 years) in