Moreno Albert (congawar85)

Seawater desalination is an alternative technology to provide safe drinking water and to solve water issues in an area having low water quality and limited drinking water supply. Currently, reverse osmosis (RO) is commonly used in the desalination technology and experiencing significant growth. The aim of this study was to analyze the environmental impacts of the seawater reverse osmosis (SWRO) plant installed in Kampung Pantai Senok, Kelantan, as this plant was the first installed in Malaysia. The software SimaPro 8.5 together with the ReCiPe 2016 database were used as tools to evaluate the life cycle assessment (LCA) of the SWRO plant. The results showed that the impact of global warming (3.90 kg CO2 eq/year) was the highest, followed by terrestrial ecotoxicity (1.62 kg 1,4-DCB/year) and fossil resource scarcity (1.29 kg oil eq/year). The impact of global warming was caused by the natural gas used to generate the electricity, mainly during the RO process. Reducing the environmental impact can be effectively achieved by decreasing the electricity usage for the seawater desalination process. As a suggestion, electricity generation can be overcome by using a high-flux membrane with other suitable renewable energy for the plant such as solar and wind energy.Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear. Low levels of ROS and enhanced antioxidant defenses are shown to contribute to increasing radioresistance. However, the role of Nrf2-Keap1-Bach1 signaling in the radioresistance of BCSCs remains elusive. Fractionated radiation increased the percentage of the ALDH-expressing subpopulation and their sphere formation ability, promoted mesenchymal-to-epithelial transition and enhanced radioresistance in BCSCs. Radiation activated Nrf2 via Keap1 silencing and enhanced the tumor-initiating capability of BCSCs. Furthermore, knockdown of Nrf2 suppressed ALDH+ population and stem cell markers, reduced radioresistance by decreasing clonogenicity and blocked the tumorigenic ability in immunocompromised mice. An underlying mechanism of Keap1 silencing could be via miR200a, as we observed a significant increase in its expression, and the promoter methylation of Keap1 or GSK-3β did not change. Our data demonstrate that ALDH+ BCSC population contributes to breast tumor radioresistance via the Nrf2-Keap1 pathway, and targeting this cell population with miR200a could be beneficial but warrants detailed studies. Our results support the notion that Nrf2-Keap1 signaling controls mesenchymal-epithelial plasticity, regulates tumor-initiating ability and promotes the radioresistance of BCSCs.Several established school smoking prevention initiatives involve restrictions on places to smoke. The focus on tobacco control in schools is due to the risk of smoking initiation during adolescence and the perception of this life stage as a period of time when health behavior is established. Hence, this period of time is considered to be ideal for health-promoting initiatives. This paper is part of an ethnographic study on adolescents' perceptions of tobacco use. Focus groups and field observations were used to explore adolescents' smoking-related practices related to smoking bans at schools. The findings show that smoking, as a place-based practice, is influenced by locally embedded rules and carries social implications resulting in a distinction between smokers and non-smokers. The distinction between smokers and non-smokers contributes to the retention of a stereotypical view of smokers and, moreover, stigmatizes smokers. According to this, restrictions on places to smoke within the school should be considered carefully in order to avoid stigma or ethical issues. Patients with lung cancer (LC) are at significantly higher risk of developing venous thromboembolism (VTE), which may lead to increased use of health resources and the cost of management. Th