Hauser Berger (columnpoison66)

AIM OF STUDY The aim of this study was to collect and analyse data on relapsing-remitting multiple sclerosis (RRMS) patients receiving disease-modifying therapies (DMTs) in Poland. MATERIAL AND METHODS This observational, multicentre study with prospective data collection included RRMS patients receiving DMTs reimbursed by the National Health Fund (NFZ) in Poland, monitored by the Therapeutic Programme Monitoring System (SMPT). Demographic profiles, disability status, and treatment modalities were analysed. RESULTS Data from 11,632 RRMS patients was collected (from 15,368 new prescriptions), including 10,649 patients in the first-line and 983 in the second-line therapeutic programme of DMTs. The proportion of females to males was 2.39 in the first-line and 1.91 in the second-line. The mean age at DMTs start was 36.6 years in the first-line and 35.1 in the second-line. The median time from the first symptoms to MS diagnosis was 7.4 months, and from MS diagnosis to treatment it was 18.48 months. A total of 43.4% of MS patients started DMT during the 12 months following diagnosis. There was a positive correlation between the duration from MS diagnosis to the start of DMT and a higher initial EDSS value [correlation 0.296 (p less then 0.001)]. About 10% of patients stopped DMTs. In Poland, about one third of all MS patients are treated in both lines, and the choice of first-line treatment depends on the region of the country. CONCLUSIONS In Poland there is a need to increase MS patient access to DMTs by improving the organisation of drug programmes.AIM OF THE STUDY Orthostatic hypotension presents in all phases of Parkinson's Disease (PD) and occurs in about 80% of patients. There is some debate in the literature as to the relationship of orthostasis to the standard drug treatments. A distinct tendency towards hypotension has been found, especially for treatment with levodopa (LD). We therefore wanted to investigate the influence of LD on blood pressure response in PD patients. METHODS We examined prospectively PD patients using lying-to-standing orthostatic tests (the modified Schellong test). The patients underwent measurements on two consecutive days, starting in the morning after a 12-hour period of restriction of food and medication. The second measurement ensued under the same condition of food restriction but consecutive to their usual LD dosage. Measurements were performed every minute for 10 minutes after rising. Measurements compared the maximum drop in blood pressure to the average resting blood pressure (after a 10-minute period of lying rec as essentially causing this state. Our study did not confirm this supposition, but rather revealed merely a minor association in individual cases.BACKGROUND Minimally Invasive Colorectal Surgery (MICS) is continually evolving. The recognition of the anus as a natural orifice to perform MICS has contributed to the development of a new philosophy of treatment called TransAnal Minimally Invasive Surgery (TAMIS). Transanal total mesorectal excision (TaTME) is one of the most common forms of TAMIS. Other indications include benign diseases and early malignant rectal adenocarcinoma. This report presents the author's experience with TAMIS as a multi-purpose operation. PATIENTS AND METHODS Between January 2015 and May 2019, 36 patients underwent TAMIS for benign and early malignant diseases (group 1) and 30 patients underwent TaTME (group 2). The mean ± SD age was 60.2 ± 13.9 years (range 28-84) (group 1) and 63.7 ± 8.6 years (47-87) (group 2). The mean ± SD BMI was 26.7 ± 5.2 kg/m2 (19.3-42.9) (group 1) and 25.7 ± 5.9 kg/m2 (17.3-50.7) (group 2). The conditions in group 1 consisted of anastomotic leakage (n=20), benign rectal stenosis (2), anastomotic explora ergonomic conditions, with completely reusable materials, and with a magnified view of the operative field, allowing intraluminal surgical sutures.OBJECTIVE Patients with advanced diabetic nephropathy benefit from kidney transplant