Lindgreen Halberg (cokegrip2)

Finally, we report a significant interaction between the change in pubertal stage and age in the development of fibre density, for left-lateralised association tracts. Overall, white matter development across ages 9-13 years involves the expansion of major white matter fibre pathways, with key association pathways linked with pubertal stage.Most individuals are willing to forego resources for the benefit of others, but their willingness to do so typically declines as a function of social distance between the donor and recipient, a phenomenon termed social discounting. We recently showed that participants were more altruistic towards strangers when a costly generous choice was framed as preventing a monetary loss to the other rather than granting them a gain. Here, we asked if acute stress would diminish this frame effect on social discounting. To test this hypothesis, 102 male participants engaged in either the Maastricht Acute Stress Task, or a matched, non-stressful control procedure. They subsequently played a two-frame dictator game version of the social discounting paradigm. Whereas both frame conditions were economically equivalent, in the give frame, participants were asked how much money they would share with other persons on variable social distance levels, and in the take frame, they decided on how much money to take away from the others. While non-stressed control participants showed increased generosity toward strangers in the take compared to the give frame, similar to previous findings of our group, stress attenuated this frame effect on social discounting by reducing generosity toward strangers in the take frame. These findings confirm that stress can corrupt prosocial motives and social norm compliance, diminishing prosocial tendencies toward unfamiliar others. Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula. It has been used for the treatment of ischemic stroke for many years in clinical. Bax apoptosis However, its pharmacological mechanism is unclear. The aim of the current study was to understand the protective effects and underlying mechanisms of DZT on ischemic stroke. Fifteen representative chemical markers in DZT were determined by ultra-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). The protective effect of DZT against ischemic stroke was studied in a rat model of middle cerebral artery occlusion (MCAO), and the mechanism was further explored through a combination of network pharmacology and experimental verification. Quantitative analysis showed that the contents of phenolic acids, furan sulfonic acids, tanshinones, flavonoids, saponins and phthalides in DZT were calculated as 7.47, 0.788, 0.627, 0.531 and 0.256mg/g, respectively. Phenolic acids were the most protected against cerebral ischemic injury. The inhibition of TXA level, platelet aggregation and thrombosis formation might involve in the protective mechanism. DZT protected against cerebral ischemic injury. The inhibition of TXA2 level, platelet aggregation and thrombosis formation might involve in the protective mechanism. This study was designed to search for ancient parasites in abdominal content and coprolites from Bolivian mummies. Twelve mummified individuals from the Andean highlands, housed at the National Museum of Archaeology (MUNARQ) in La Paz, Bolivia. Microscopic analysis of rehydrated samples (coprolites and abdominal content), following Lutz's spontaneous sedimentation technique. Eggs of Enterobius vermicularis were identified in coprolites from one mummy, and capillariid eggs in the organic abdominal content from another individual. This is the first evidence of ancient intestinal parasites in Bolivian mummies. This pioneering study focused on the search of ancient intestinal parasites in human remains of