Lillelund Townsend (browwave28)

05).Correlation analysis suggested that cEPCs, ESM-1 and vWF were positively correlated with TM and PAI-1 (r=0.561, 0.576, P less then 0.05;r=0.558, 0.603, P less then 0.05;r=0.677, 0.692, P less then 0.05).In conclusion, plasma TM and PAI-1 are closely related to the severity of endothelial cell injury in patients with sepsis. The more serious the damage of endothelial cells is, the higher the TM, PAI-1,cEPCs,ESM-1 and vWF levels are, which could be criterion for treatment evaluation.To investigate the prophylaxis and treatment of venous thromboembolism (VTE) in intensive care units (ICU) in Zhejiang Province. A cross-sectional questionnaire survey for ICUs doctors was conducted online at 41 tertiary hospitals in Zhejiang Province, which included basic information of ICUs, VTE-related installations, knowledge and monitoring system. The data collected from the questionnaire were summarized and analyzed. Most ICUs were comprehensive. The ratio of physicians to beds, ratio of nurses to beds, and the ratio of rehabilitation physicians to beds were 0.52∶1, 2.12∶1, and 0.03∶1 respectively. Thirty-five over 41 (85.4%) ICUs completed VTE risk assessment within 24 hours. Twenty-five over 35 ICUs (71.4%) chose the Caprini model to assess VTE risk. Ultrasound was preferred in 92.7% (38/41) of ICUs equipped ultrasound. Almost all (40/41, 97.6%) of hospitals possessed intermittent pneumatic compression (IPC) as mechanical prophylaxis. The ratio of IPC to bed was 0.22∶1. Low-molecular-weight heparin (92.7%, 38/41) was the initial treatment in ICUs. VTE prophylaxis system has been established in 92.7% (38/41)hospitals and 87.8% (36/41) ICUs,related personnel groups were set up in 75.6% (31/41) hospitals and 58.5% (24/41) ICUs including 68.3% (28/41) hospitals with multidisciplinary team. VTE prophylaxis system in different hospitals was heterogeneous. VTE risk assessment models in different ICUs were not identical. There were unmet clinical needs of VTE mechanical prophylaxis equipment. In conclusion, VTE screening, evaluation and prophylaxis protocols in ICUs still need to be standardized and improved.Objective To retrospectively analyze the relationship between serum C-reactive protein (CRP), serum cholinesterase (ChE), prealbumin (PA) and mortality in severe patients with coronavirus disease 2019 (COVID-19). Methods During the period from January 29 to March 30, 2020, a total of 344 COVID-19 patients were admitted to west branch of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. One-hundred and ninety-two patients were diagnosed with common type and excluded, and 34 patients were transferred to LeiShenShan or other medical units. The remaining 118 patients were severe cases, and 18 cases were excluded due to incomplete data. A total of 100 severe COVID-19 patients were finally collected. According to the outcome, the patients were divided into death group (37 cases) and survival group(63 cases), and the levels of serum CRP, ChE and PA were compared. Statistical analysis were performed by SPSS25.0. Results There were 53 male patients in this study. The level of CRP in death group was significantly more elevated compare to the survival group [(95.72±39.56) mg/L vs. (22.21±20.75) mg/L, P less then 0.01]. On the contrary, serum ChE in death group was remarkably decreased [(5 082±1 566) U/L vs. (7 075±1 680) U/L, P less then 0.01]. Also, serum PA in death group was significantly lower [(86.18±47.94) mg/L vs. (167.40±57.82) mg/L, P less then 0.01]. Univariate analysis showed that CRP and PA had an impact on the survival of critical patients, but multivariate Cox regression analysis suggested that CRP was the independent factor affecting the survival of critical patients. Conclusions CRP is generally elevated in severe patients with COVID-19, and serum ChE and PA accordingly decrease. CRP and PA have influence on patients' survival, but only CRP demonstrates predictive value for prognosis in critical pat