Hartley Antonsen (birthear29)

Levodopa-carbidopa intestinal gel (LCIG) is administered directly to the small intestine of patients with advanced Parkinson's disease (APD) to help maintain stable plasma levodopa levels. The objective of this study was to investigate the effect of LCIG in reducing polypharmacy for the treatment of APD. The COmedication Study assessing Mono- and cOmbination therapy with levodopa-carbidopa inteStinal gel (COSMOS) is a large, real-world, multinational observational study investigating comedication use with LCIG. All enrolled patients had used LCIG for ≥12 months and data were collected cross-sectionally (study visit) and retrospectively. The primary endpoint was the percentage of patients using LCIG as monotherapy (without add-on PD medications) at initiation and at 3, 6, 9, and 12 months thereafter. Overall, 409 patients were enrolled from 14 countries and were treated with LCIG for a mean of 35.8 ± 23.2 months. A total of 15.2% of patients initiated LCIG as monotherapy and 31.7% were receiving monothnt Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Although disciplinary data on violations committed by licensed mental health professionals are important information for training programs, supervisors, and regulators, little disciplinary information is available on licensed marriage and family therapists (MFTs). This study collected data publicly available from state regulatory board websites and open records requests from 35 states for a total of 1241 separate cases, 889 of which were from CA. The findings indicated that the five most common violations for MFTs in 34 states (not including CA) were nonsexual dual relationships, failure to meet CE hour requirements, sexual dual relationships, unlicensed practice, and misrepresentation on licensing applications or renewals. For CA, the most common violations included criminal charges-misdemeanor, DUI/inappropriate substance use, unprofessional conduct, misrepresentation on licensure paperwork, and failure to meet CE hour requirements. Selleckchem HC-258 MFTs licensed between 2 and 5 years committed the majority of violations. Implications for training programs, supervisors, and regulators are discussed. Debate continues in regard to the optimal surgical approach to the mitral valve for degenerative disease. Between February 2004 and July 2015, 363 patients underwent mitral valve repair for degenerative mitral valve disease via either sternotomy (sternotomy, n = 109) or small right anterior thoracotomy (minimally invasive, n = 259). Survival, need for mitral valve reoperation, and progression of mitral regurgitation more than two gradeswere compared between cohorts using time-based statistical methods and inverse probability weighting. Survival at 1, 5, and 10 years were 99.2, 98.3, and 96.8 for the sternotomy group and 98.1, 94.9, and 94.9 for the minimally invasive group (hazard ratio 0.39, 95% confidence interval [CI] 0.11-1.30, p = .14). The cumulative incidence of need for mitral valve reoperation with death as a competing outcome at 1, 3, and 5 years were 2.7%, 2.7%, and 2.7% in the sternotomy cohort and 1.5%, 3.3%, and 4.1% for the minimally invasive group (subhazard ratio (SHR) 1.17, 95% CI 0.33-4.20, p = .81). Cumulative incidence of progression of mitral regurgitation more than two grades with death as a competing outcome at 1, 3, and 5 years were 5.5%, 14.4%, and 44.5% for the sternotomy cohort and 4.2%, 9.7%, and 20.5% for the minimally invasive cohort (SHR 0.67, 95% CI 0.28-1.63, p = .38). Inverse probability weighted time-based analyses based on preoperative cohort assignment also demonstrated equivalent outcomes between surgical approaches. Minimally invasive and sternotomy mitral valve repair in patients with degenerative mitral valve disease is associated with equivalent survival and repair durability. Minimally inva