Morgan McNulty (beamlow91)

In addition, we demonstrated that Rab7 and RILP, but not Rab5, localizes to LDs of infected macrophages and observed the presence of Rab7 at the site of interaction with an infected phagosome. Moreover, treatment of macrophages with the Rab7 inhibitor CID1067700 significantly inhibited the association between LDs and LAM-coated beads. Altogether, our data demonstrate that LD-phagosome interactions are controlled by mycobacterial cell wall components and Rab7, which enables the exchange of contents between LDs and phagosomes and may represent a fundamental aspect of bacterial pathogenesis and immune evasion. V.PURPOSE The purpose of this study was to examine the changes in the mandibular border movement between class II and class III jaw deformity patients before and after orthognathic surgery, by using the same device. SUBJECTS and Methods Eighty one patients (28 in class II and 53 in class III) who underwent sagittal split ramus osteotomy (SSRO) with Le Fort I osteotomy using absorbable plate fixation and 27 controls with normal occlusion were enrolled. Mandibular border movement (observed using a kinesiograph) was recorded with a mandibular movement measure system (K7) before surgery, and at 6 months and 1 year after surgery. Time-course changes of 5 components of the mandibular border movement (MVO Maximum vertical opening, CO to MAP Maximum antero-posterior movement from centric occlusion, MLDL maximum lateral deviation left, MLDR maximum lateral deviation right, CO to MO centric occlusion to maximum opening) were compared between classes II, III and controls statistically. The relationship between lateral ceplass III (P = 0.0001, P = 0.0007 and P  less then  0.0001), although there was no significant difference between pre-operation and after 1 year in class II. In CO to MO, class II (mean and standard deviation 39.6 ± 10.5 mm) and class III (mean and standard deviation 47.3 ± 8.4 mm) still remained smaller values than control (mean and standard deviation 52.7 ± 9.2 mm) after 1 year (P  less then  0.0001 and P = 0.0095). CONCLUSION This study suggests that bi-maxillary surgery can have more influence on the reduction in the range of mandibular border movement including vertical or antero-posterior motion than lateral deviation motion, in both groups. The difference in the time-course change in the mandibular border movement between the groups might depend more on the mandibular length than on the movement direction of the mandible by surgery such as advancement or setback. BACKGROUND Robotic devices are often used in rehabilitation and might be efficient to improve walking capacity after stroke. OBJECTIVE First to investigate the effects of robot-assisted gait training after stroke and second to explain the observed heterogeneity of results in previous meta-analyses. METHODS All randomized controlled trials investigating exoskeletons or end-effector devices in adult patients with stroke were searched in databases (MEDLINE, EMBASE, CENTRAL, CINAHL, OPENGREY, OPENSIGLE, PEDRO, WEB OF SCIENCE, CLINICAL TRIALS, conference proceedings) from inception to November 2019, as were bibliographies of previous meta-analyses, independently by 2 reviewers. The following variables collected before and after the rehabilitation program were gait speed, gait endurance, Berg Balance Scale (BBS), Functional Ambulation Classification (FAC) and Timed Up and Go scores. We also extracted data on randomization method, blinding of outcome assessors, drop-outs, intention (or not) to treat, country, number of participants, disease duration, mean age, features of interventions, and date of outcomes assessment. RESULTS We included 33 studies involving 1466 participants. On analysis by subgroups of intervention, as compared with physiotherapy alone, physiotherapy combined with body-weight support training and robot-assisted gait training conferred greater im