Kuhn Barton (barberjoseph28)

Rauwolfia serpentina has a wide range of therapeutic effects so this study was planned to explore the antihypertensive and antihyperlipidemic therapeutic responses of R serpentina doses using albino rats by measuring the blood pressure, biochemical parameters, and histological architecture of liver and kidney tissues. Thirty albino rats were divided into 5 groups (n = 6) as G1 (normal Control) received normal diet, G2 (positive control) received only 8% NaCl added diet (high salt diet); G3 was given atenolol (standard drug control) 50 mg/kg body weight, G4 and G5 groups were given methanolic plant extract as low dose (100 mg/kg body weight) and high dose (200 mg/Kg body weight) daily along with high salt diet for 4 weeks, respectively. Rauwolfia serpentina significantly (P less then .05) decreased the blood pressure in G4 and G5 groups as compared to G2 and G3. Significant (P less then .05) impact was reported, on serum lipid profile and serum proteins as well as hepatoprotective and renoprotective potential on studying tissues sections under microscope, in animal groups given herbal extract as compared to control groups. It could be concluded that R serpentina has therapeutic effect to manage the hypertension and hypercholesterolemia most probably via protecting the liver and renal architectures.In view of the continuous resistance to antibacterial agents by bacteria and the existing problems of silver nanoparticles as an antibacterial agent, this study reports on the synthesis of pure zirconium oxide, silver oxide, and ZrO2-Ag2O nanoparticles by sol-gel method. The nanoparticles were analyzed and tested for their antibacterial activity against gram-positive bacteria of Bacillus subtilis, Streptococcus mutans, Staphylococcus aureus, and gram-negative of Escherichia coli, Pseudomonas aeruginosa, and Klebsiella oxytoca. X-ray diffraction showed the monoclinic ZrO2, cubic Ag2O, and peaks corresponding to ZrO2 and Ag2O in their mixed samples. Scanning electron microscopy showed spherically shaped nanoparticles while dynamic light scattering analysis showed ZrO2 (76 nm), Ag2O (50 nm), and ZrO2-Ag2O samples between 14 and 42 nm. The Fourier Transformed Infrared spectroscopy spectra of ZrO2 gave bands at 480 cm-1 to 750 cm-1 (M-O stretching) with Ag2O at 580 cm-1, while ZrO2-Ag2O samples showed bands at 760 cm-1. The screening by agar diffusion assay revealed a pronounced increase in the antibacterial activity of ZrO2-Ag2O against all the tested bacteria when compared with the pure ZrO2 and Ag2O. The improved antibacterial activity of ZrO2-Ag2O largely results from the chemical stability conferred on it by the ZrO2 as observed from the zeta potential measurement.Chronic musculoskeletal pain has biological, psychological, and social components. In this article, we have demonstrated the easily injectable nanocomposite carrier for the treatment of chronic musculoskeletal pain. Briefly, the curcumin (Cur) loaded with lipid nanocapsules (LNCs; Cur@LNCs) using the phase invasion method. The synthesized Cur@LNCs were characterized by using scanning electron microscopy, transmittance electron microscopy, and the size of the fabricated nanoparticles confirmed by dynamic light scattering analysis. The synthesized Cur@LNC injectable hydrogel shows excellent results in vivo in the rat model. We have examined the efficiency of the chronic constriction injury in the rat model and induced the pain using thermal paw withdrawal latency. find more The injectable hydrogels Cur@LNCs display a remarkable reduction in pain 7 days post administrations compared to the untreated group animals. This work could establish the preclinical candidate of the neuropathic pain response in the future. The aetiologies and pathogeneses of the joint diseases rheumatoid arthritis (RA) and spondyloarthritis (SpA) are still not fully elucidated. To increase our understanding of the molecular pathogenesis, we analysed the protein composition of synovial fluid (SF)