Vincent Jespersen (bagwater9)

(1) Background All deaths that occurred in a hospital of Southern Italy ("San Giuseppe Moscati" Hospital of Avellino) with medium jurisdiction (up to 425,000 citizens approximately) in the period from 9 March to 4 May 2020 were analyzed. The primary endpoint of the study was to analyze the causes of death in the period study. Secondary endpoints included (1) the assessment of overall mortality in the emergency period compared with the same period of the past years (2018-2019) in the jurisdiction area; (2) the assessment of the amounts of deaths with positive and negative reverse transcription-polymerase chain reaction (RT-PCR) of nasopharyngeal and oropharyngeal swabs; (3) the frequency of clinical and radiological features consistent with Covid-19 infection in negative RT-PCR cases. (2) Methods Patients' information and laboratory data were collected through the computerized medical record system (My Hospital, Italy) used for the clinical management of all referring patients. Epidemiological, clinical, and radiological data were reviewed along with the results of nasopharyngeal and oropharyngeal swabs. (3) Results From 9 March to 4 May 2020, 140 deaths (87 males, 53 females) from all causes occurred in total at "San Giuseppe Moscati" Hospital, of which 32 deaths were Covid-19 related. (4) Conclusions The excess of mortality could be higher than the one reported in the official epidemiological surveys. False negative cases can have a distorting effect on the assessment of the real mortality rate and the excess mortality. Furthermore, many who died from Covid-19 were likely never tested or they had false negative RT-PCR results. Other victims probably died from causes indirectly related to Covid-19.The two-point force-velocity model allows the assessment of the muscle mechanical capacities in fast, almost fatigue-free conditions. The aim of this study was to investigate the concurrent validity of the two-point parameters with directly measured force and power and to examine the generalization of the two-point parameters across the different functional movement tests of leg muscles. Twelve physically active participants were tested performing three functional lower limb maximal tests under two different magnitudes of loads countermovement jumps, maximal cycling sprint, and maximal force under isokinetic conditions of the knee extensors. The results showed that all values from the two-point model were higher than the values from the standard tests (p less then 0.05). We also found strong correlations between the same variables from different tests (r ≥ 0.84; p less then 0.01), except for force in maximal cycling sprint, where it was low and negligible (r = -0.24). The results regarding our second aim showed that the correlation coefficients between the same two-point parameters of different lower limb tests ranged from moderate to strong (r -0.47 to 0.72). In particular, the relationships were stronger between power variables than between force variables and somewhat stronger between standard tests and two-point parameters. We can conclude that mechanical capacities of the leg muscles can be partially generalized between different functional tests.Macrophages and related tissue macrophage populations use the classical NADPH oxidase (NOX2) for the regulated production of superoxide and derived oxidants for pathogen combat and redox signaling. With an emphasis on macrophages, we discuss how sorting into secretory storage vesicles, agonist-responsive membrane trafficking, and segregation into sphingolipid and cholesterol-enriched microdomains (lipid rafts) determine the subcellular distribution and spatial organization of NOX2 and superoxide dismutase-3 (SOD3). We discuss how inflammatory activation of macrophages, in part through small GTPase Rab27A/B regulation of the secretory compartments, mediates the coalescence of these two proteins on the cell surface to deliver a focalized hydrogen peroxide output. In interplay with membr